Clinical Effect of Zishenwan on Elderly Patients with Prediabetes Based on the Method of Sweet-Bitter Therapeutic

[Objectives]To study the clinical effect of Zishenwan on elderly patients with prediabetes based on the method of Sweet-Bitter Therapeutic.[Methods]Total 64 elderly patients with prediabetes in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine from April,2020 to July,2021 were randomly divided into control group(32 cases)and Zishenwan group(32 cases).The control group received basic treatment(diet control and regular luck exercise),while the Zishenwan group was treated with Zishenwan on the basic treatment.[Results]The results of intragroup comparisons after treatment show that both of the groups improved plasma glucose,insulin,plasma lipid metabolism and other related indexes.The results of inter-group comparisons were as follows.(i)The FPG and 2hPG of the Zishenwan group were significantly lower than the control group(P<0.05).(ii)The FINS and HOMA-IR of the Zishenwan group were significantly lower than the control group(P<0.05).(iii)The LDL-C of the Zishenwan group were significantly lower than the control group(P<0.05).(iv)The ADP,hs-CRP,and GLP-1 of the Zishenwan group were significantly improved compared to those of the control group(P<0.05).Although there was no significant difference in other indicators,the improvement trend is better than that of the control group.[Conclusions]Zishenwan can further improve plasma glucose level of the elderly patients with prediabetes on the basis of basic treatment,and to a certain extent,reduce the plasma glucose to normal,which is beneficial to the benign outcome of the elderly patients with prediabetes.In addition,it can improve insulin secretion and reduce insulin resistance,which provides a basis for the disease control of elderly patients with prediabetes.It can also improve the lipid metabolism of elderly patients with prediabetes,and the effect on LDL-C is significant.It is speculated that its mechanism may be closely related to the changes of ADP,hs-CRP and GLP-1 in the body of elderly patients with prediabetes.

Migration and fate of polycyclic aromatic hydrocarbons in bioretention systems with different media:experiments and simulations

Polycyclic aromatic hydrocarbons(PAHs)present significant risks to human health owing to their carcinogenic,teratogenic,and mutagenic properties.The contamination of surface water with PAHs via runoff has become a prominent source of water pollution.While the capacity of bioretention systems to remove PAHs from runoff is recognized,the dynamics of PAH migration and degradation in these systems are not well-understood.This study aims to explain the migration and fate of PAHs in bioretention systems through a series of experiments and model simulations.This study constructed bioretention systems with three different media types and found that these systems achieved PAH load reductions exceeding 92%.Notably,naphthalene(NAP),fluoranthene(FLT),and pyrene(PYR)tended to accumulate in the media’s upper layer,at depths of 10 to 40 cm.To further analyze the migration and fate of PAHs during multi-site rainfall events and across prolonged operation,we applied the HYDRUS-1D model under three distinct scenarios.The findings of this study indicated that NAP degraded in 40 d,whereas FLT and PYR showed incomplete degradation after 120 d.During continuous rainfall events,there was no clear pattern of PAH accumulation;however,FLT and PYR persisted in the bioretention systems.The combination of experimental and simulation findings highlights the inevitable accumulation of PAHs during extended use of bioretention systems.This research provides a theoretical basis for improving operational efficiency,advancing PAH degradation in bioretention systems,and reducing their toxicity.

Fractal characteristics of round jets in steady crossflow

The fractal dimensions of turbulent round jets in steady crossflow has been analyzed by using planar laser-induced fluorescence (PLIF) method. The relation between the fractal dimension and the momentum ratio, the variation of the fractal dimension with the elevation of jet and the dilution have been investigated. The comparison of the fractal characteristics between the multiple jets and the signal jet has been carried out.