Duplication and divergence have been widely recognized as the two domi- nant evolutionary forces in shaping biological networks, e.g., gene regulatory networks and protein-protein interaction （PPI） networks. It has ...Duplication and divergence have been widely recognized as the two domi- nant evolutionary forces in shaping biological networks, e.g., gene regulatory networks and protein-protein interaction （PPI） networks. It has been shown that the network growth models constructed on the principle of duplication and divergence can recapture the topo- logical properties of real PPI networks. However, such network models only consider the evolution processes. How to select the model parameters with the real biological experi- mental data has not been presented. Therefore, based on the real PPI network statistical data, a yeast PPI network model is constructed. The simulation results indicate that the topological characteristics of the constructed network model are well consistent with those of real PPI networks, especially on sparseness, scale-free, small-world, hierarchical modularity, and disassortativity.展开更多
The femtosecond laser has a number of advantages,.such as short pulse time,.high instantaneous power,.high repetition rate, low monopulse energy, and small thermal effect. Femtosecond laser-assisted small incision len...The femtosecond laser has a number of advantages,.such as short pulse time,.high instantaneous power,.high repetition rate, low monopulse energy, and small thermal effect. Femtosecond laser-assisted small incision lenticule extraction(SMILE) is becoming the new direction in refractive surgery,and the ocular surface changes after SMILE are attracting increasingly more attention. This article reviews adverse effects,including dry eye, injury of corneal nerves, and ocular surface inflammation,.occurring after SMILE.展开更多
Endometrial stromal tumors(ESTs)include endometrial stromal nodule(ESN),low-grade endometrial stromal sarcoma(LG-ESS),high-grade endometrial stromal sarcoma(HG-ESS),and undifferentiated uterine sarcoma(UUS).Since thes...Endometrial stromal tumors(ESTs)include endometrial stromal nodule(ESN),low-grade endometrial stromal sarcoma(LG-ESS),high-grade endometrial stromal sarcoma(HG-ESS),and undifferentiated uterine sarcoma(UUS).Since these are rare tumor types,there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS.Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs,and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE)-family with sequence similarity 22(FAM22)fusion.Recently,a group of ESSs harboring both zinc finger CCCH domain-containing protein7 B(ZC3H7B)-B-cell lymphoma 6 corepressor(BCOR)fusion and internal tandem duplication(ITD)of the BCOR gene have been provisionally classified as HG-ESSs.In this review,we firstly describe current knowledge about the molecular characteristics of recurrent aberrant proteins and their roles in the tumorigenesis of LG-ESSs and HG-ESSs.Next,we summarize the possibly shared signal pathways in the tumorigenesis of LG-ESSs and HG-ESSs,and list potentially actionable targets.Finally,based on the above discussion,we propose a few promising therapeutic strategies for LG-ESSs and HG-ESSs with recurrent gene alterations.展开更多
Gadolinium methacrylate（Gd（MAA）3） was synthesized by using gadolinium oxide and methacrylic acid as the starting materials and its self-polymerization kinetic was studied based on non-isothermal and isothermal ana...Gadolinium methacrylate（Gd（MAA）3） was synthesized by using gadolinium oxide and methacrylic acid as the starting materials and its self-polymerization kinetic was studied based on non-isothermal and isothermal analysis. Moreover, the monomer reactivity ratios of methyl methacrylate（MMA） and Gd（MAA）3 were evaluated by using Kelen-Tiidos method. The thermal neutron shielding properties of PMMA and poly（MMA-co-Gd（MAA）3） were calculated by MCNP program. The results show that the selfpolymerization of Gd（MAA）3 can be initiated by thermal and free radical and its activation energy is103.35 kJ/mol or 58.55 kJ/mol correspondingly in the solid state or aqueous solution. The polymerization rate,Rp,under low conversion at 65 ℃ is expressed as Rp = K[M]^（1.05）[I]^（0.60）. The reactivity ratios of r1（MMA） and r2（Gd（MAA）3） are 0.225 and 1.340, respectively. The ability of thermal neutron shielding of poly（MMA-co-Gd（MAA）3） is increased by gadolinium contents and is far better than PMMA.展开更多
The China Spallation Neutron Source is an accelerator-based user facility for neutron,proton,muon applications and so on.The designed proton beam power is 100 kW for the first phase.Overall,the scope of accelerator co...The China Spallation Neutron Source is an accelerator-based user facility for neutron,proton,muon applications and so on.The designed proton beam power is 100 kW for the first phase.Overall,the scope of accelerator control system covers four parts,the global systems,the device layer local controls and remote controls,the high-level applications and services and the integration of conventional facilities.The principle guideline is to adopt as many as possible matured technologies and commercial products in the design and implementation.The control system is based on Experimental Physics and Industrial Control System.VME64x bus is chosen for timing system and fast protection system.PLCs and embedded industrial computers are used in the device layer slow controls.Control System Studio is adopted as the high-level applications.Blade server-based virtualization platform is deployed for the computer system.The accelerator control system was completed in September 2017 and then transited to routine operations.The design,implementation and operation of the accelerator control system are described in this paper.展开更多
基金Project supported by the National Natural Science Foundation of China(No.11172158)
文摘Duplication and divergence have been widely recognized as the two domi- nant evolutionary forces in shaping biological networks, e.g., gene regulatory networks and protein-protein interaction （PPI） networks. It has been shown that the network growth models constructed on the principle of duplication and divergence can recapture the topo- logical properties of real PPI networks. However, such network models only consider the evolution processes. How to select the model parameters with the real biological experi- mental data has not been presented. Therefore, based on the real PPI network statistical data, a yeast PPI network model is constructed. The simulation results indicate that the topological characteristics of the constructed network model are well consistent with those of real PPI networks, especially on sparseness, scale-free, small-world, hierarchical modularity, and disassortativity.
基金Surface Project of National Natural Science Foundation of China(No:81270979)
文摘The femtosecond laser has a number of advantages,.such as short pulse time,.high instantaneous power,.high repetition rate, low monopulse energy, and small thermal effect. Femtosecond laser-assisted small incision lenticule extraction(SMILE) is becoming the new direction in refractive surgery,and the ocular surface changes after SMILE are attracting increasingly more attention. This article reviews adverse effects,including dry eye, injury of corneal nerves, and ocular surface inflammation,.occurring after SMILE.
基金supported by the WU JIEPING MEDICAL FOUNDATION(No.320.6750.18489),China。
文摘Endometrial stromal tumors(ESTs)include endometrial stromal nodule(ESN),low-grade endometrial stromal sarcoma(LG-ESS),high-grade endometrial stromal sarcoma(HG-ESS),and undifferentiated uterine sarcoma(UUS).Since these are rare tumor types,there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS.Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs,and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE)-family with sequence similarity 22(FAM22)fusion.Recently,a group of ESSs harboring both zinc finger CCCH domain-containing protein7 B(ZC3H7B)-B-cell lymphoma 6 corepressor(BCOR)fusion and internal tandem duplication(ITD)of the BCOR gene have been provisionally classified as HG-ESSs.In this review,we firstly describe current knowledge about the molecular characteristics of recurrent aberrant proteins and their roles in the tumorigenesis of LG-ESSs and HG-ESSs.Next,we summarize the possibly shared signal pathways in the tumorigenesis of LG-ESSs and HG-ESSs,and list potentially actionable targets.Finally,based on the above discussion,we propose a few promising therapeutic strategies for LG-ESSs and HG-ESSs with recurrent gene alterations.
基金Project supported by Graduate Student Research Innovation Project(KYLX_1337)
文摘Gadolinium methacrylate（Gd（MAA）3） was synthesized by using gadolinium oxide and methacrylic acid as the starting materials and its self-polymerization kinetic was studied based on non-isothermal and isothermal analysis. Moreover, the monomer reactivity ratios of methyl methacrylate（MMA） and Gd（MAA）3 were evaluated by using Kelen-Tiidos method. The thermal neutron shielding properties of PMMA and poly（MMA-co-Gd（MAA）3） were calculated by MCNP program. The results show that the selfpolymerization of Gd（MAA）3 can be initiated by thermal and free radical and its activation energy is103.35 kJ/mol or 58.55 kJ/mol correspondingly in the solid state or aqueous solution. The polymerization rate,Rp,under low conversion at 65 ℃ is expressed as Rp = K[M]^（1.05）[I]^（0.60）. The reactivity ratios of r1（MMA） and r2（Gd（MAA）3） are 0.225 and 1.340, respectively. The ability of thermal neutron shielding of poly（MMA-co-Gd（MAA）3） is increased by gadolinium contents and is far better than PMMA.
文摘The China Spallation Neutron Source is an accelerator-based user facility for neutron,proton,muon applications and so on.The designed proton beam power is 100 kW for the first phase.Overall,the scope of accelerator control system covers four parts,the global systems,the device layer local controls and remote controls,the high-level applications and services and the integration of conventional facilities.The principle guideline is to adopt as many as possible matured technologies and commercial products in the design and implementation.The control system is based on Experimental Physics and Industrial Control System.VME64x bus is chosen for timing system and fast protection system.PLCs and embedded industrial computers are used in the device layer slow controls.Control System Studio is adopted as the high-level applications.Blade server-based virtualization platform is deployed for the computer system.The accelerator control system was completed in September 2017 and then transited to routine operations.The design,implementation and operation of the accelerator control system are described in this paper.
