Macromolecule’s Orientation in a Nanofiber by Bubble Electrospinning

In the search for sustainable alternatives to harmful synthetic fibers,an increasing amount of research focuses on biomimicry and natural fibers.Sea silk is an exceptional textile material.It is a kind of natural silk produced using the long silky filaments secreted by a specific bivalve mollusk(Pinna nobilis);now at edge of extinction.This paper suggests a simple but effective way to prepare artificial sea silk from Mytilus edulis.A sea silk solution is prepared using a Mytilus edulis protein,and a polyvinyl alcohol(PVA)solution is mixed with the sea silk solution in order to produce artificial sea silk through a bubble electrospinning technique.The effects of the sea silk concentration on the nanofiber’s morphology and mechanical properties are studied experimentally.

Focus on HFpEF in heart failure

There are so many of our patients who have had heart failure with preserved ejection fraction(HFpEF)and management really remains problematic.Approximately half of the patients with heart failure have preserved left ventrical(LV)systolic function and usually have some degree of diastolic dysfunction.Patients with reduced or preserved systolic function may have similar symptoms and it may be difficult to distinguish clinically between the two based on signs and symptoms.In developed countries,coronary artery disease(CAD)with resulting myocardial infarction and loss of functioning myocardium(ischemic cardiomyopathy)is the most common cause of systolic heart failure.Systemic hypertension remains an important cause of heart failure and,even more commonly in the United States,an exacerbating factor in patients with cardiac dysfunction because of other causes,such as CAD.Several processes may present with dilated or congestive cardiomyopathy,which is characterized by LV or biventricular dilation and generalized systolic dysfunction.Rare causes of dilated cardiomyopathy include infiltrative diseases(hemochromatosis,sarcoidosis,and amyloidosis),other infectious agents,metabolic disorders,cardiotoxins,and medication toxicity.Valvular heart diseases—particularly degenerative aortic stenosis and chronic aortic or mitral regurgitation—are frequent causes of heart failure.Persistent tachycardia,often related to atrial arrhythmias,can cause systolic dysfunction that may be reversible with controlling the rate.Diastolic cardiac dysfunction is associated with aging and related myocardial stiffening,as well as left ventricular hypertrophy(LVH),commonly resulting from hypertension.Conditions such as hypertrophic or restrictive cardiomyopathy,diabetes,and pericardial disease can produce the same clinical picture.Atrial fibrillation with or without rapid ventricular response may contribute to impaired left ventricular filling.