As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of ...As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer.展开更多
We define a new type cryptographical model called secure multi-party proof that allows any players and a verifier to securely compute a function : each of the players learns nothing about other players’ input and abo...We define a new type cryptographical model called secure multi-party proof that allows any players and a verifier to securely compute a function : each of the players learns nothing about other players’ input and about the value of , and the verifier obtains the value of and it’s validity but learns nothing about the input of any of the players. It is implemented by a protocol using oblivious transfer and Yao’s scrambled circuit. We prove that our protocol is secure if the players and the verifier are semi-honest (i.e. they follow the protocol) and polynomial time bounded. The main applications of our protocol are for electronic voting and electronic bidding.展开更多
∑-protocol has been proved to be a very powerful cryptographic tool and widely used in nnmerous important cryptographic applications. In this paper, the authors make use of ∑-protocol as a main tool to resolve the f...∑-protocol has been proved to be a very powerful cryptographic tool and widely used in nnmerous important cryptographic applications. In this paper, the authors make use of ∑-protocol as a main tool to resolve the following difficult problems 1-3 and to construct three ettlcient cryptographic protocols 4 6：1） How to construct a protocol for proving a secret integer to be a Blum integer with form PQ, where P, Q are two different primes and both -- 3（mod 4）;2） How to construct a protocol for proving a secret polynomial with exact degree t - 1 iil a （t, n）- threshold secret sharing scheme：3） How to construct witness indistinguishable and witness hiding protocol not from zero-knowledge proof;4） A publicly verifiable secret sharing scheme with information-theoretic security;5） A delegateable signature scheme under the existence of one-way permutations;6） Non-interactive universal designated verifier signature schemes.展开更多
基金the National Natural Science Foundation of China(No.82073308 and No.81773211)the High-level startup fund of Nanjing Medical University(No.KY109RC2019010).
文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer.
文摘We define a new type cryptographical model called secure multi-party proof that allows any players and a verifier to securely compute a function : each of the players learns nothing about other players’ input and about the value of , and the verifier obtains the value of and it’s validity but learns nothing about the input of any of the players. It is implemented by a protocol using oblivious transfer and Yao’s scrambled circuit. We prove that our protocol is secure if the players and the verifier are semi-honest (i.e. they follow the protocol) and polynomial time bounded. The main applications of our protocol are for electronic voting and electronic bidding.
基金supported by the Foundation of tihe National Natural Science of China under Grant Nos 90604034 (Key Project), 10726012, 10871222, 10531040,and 10471156
文摘∑-protocol has been proved to be a very powerful cryptographic tool and widely used in nnmerous important cryptographic applications. In this paper, the authors make use of ∑-protocol as a main tool to resolve the following difficult problems 1-3 and to construct three ettlcient cryptographic protocols 4 6：1） How to construct a protocol for proving a secret integer to be a Blum integer with form PQ, where P, Q are two different primes and both -- 3（mod 4）;2） How to construct a protocol for proving a secret polynomial with exact degree t - 1 iil a （t, n）- threshold secret sharing scheme：3） How to construct witness indistinguishable and witness hiding protocol not from zero-knowledge proof;4） A publicly verifiable secret sharing scheme with information-theoretic security;5） A delegateable signature scheme under the existence of one-way permutations;6） Non-interactive universal designated verifier signature schemes.
