Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3...Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3),SLA II,and SLA III(Smith et al.,2005).SLA I plays an important role in cellular immunity which can eliminate viruses and other foreign antigens in pigs(Macdonald et al.,2010).SLA-1,SLA-2 and SLA-3 are important SLA I alleles and are highly polymorphic.Polymorphism causes extreme difficulties in screening broadly protective cytotoxic lymphocyte(CTL)epitope antigens.The supertype which is built based on peptide-binding specificity of each SLA I can overcome this difficulty to some extent(Thomsen et al.,2013).展开更多
基金Financed by the National Key R&D Program of China(2017YFD0502302)National 12th Five-Year Plan Science and Technology Support Project(2015BAD12B01-06).
文摘Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3),SLA II,and SLA III(Smith et al.,2005).SLA I plays an important role in cellular immunity which can eliminate viruses and other foreign antigens in pigs(Macdonald et al.,2010).SLA-1,SLA-2 and SLA-3 are important SLA I alleles and are highly polymorphic.Polymorphism causes extreme difficulties in screening broadly protective cytotoxic lymphocyte(CTL)epitope antigens.The supertype which is built based on peptide-binding specificity of each SLA I can overcome this difficulty to some extent(Thomsen et al.,2013).
