Afundamental question for meiosis is how homologous chromosomes （homologs） find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to ...Afundamental question for meiosis is how homologous chromosomes （homologs） find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to the interaction between homologous sequences. However, that is not the whole story according to some studies on the role of cohesins in homolog pairing. The most recent one by Ishiguro et al. of the Watanabe group indicates that chromosome architecture defined by a meiosis-specific cohesin protein RAD21L is the key to homology searching. Moreover, they report that homologous pairing is dependent on neither SPOll, an evolutionarily conserved type 2 isomerase responsible for generating DNA double-strand breaks （DSBs）, nor SUN1, which tethers the ends of chromosomes to the nuclear envelop （NE） and facilitates chromosome movement and bouquet formation. These discoveries are quite some surprises!展开更多
Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Cha...Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Chaible et al,2010).At pre-sent,a variety of tools act at the DNA or RNA level to enable researchers to model gene function(and thus protein)deficiency,including nucleic acid based RNA interference(EI-bashir et al.,2001),antisense oligonucleotides(Schoch and Miller,2017),and genome editing-based CRISPR-Cas9(Doudna and Charpentier,2014)strategies.However,challenges remain.展开更多
Following the publication of the US National Research Council （N RC） report ＂ Toward PrecMon Medicine.＂ Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases＂ in 2011 [1], several n...Following the publication of the US National Research Council （N RC） report ＂ Toward PrecMon Medicine.＂ Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases＂ in 2011 [1], several nations have announced that their national research programs would definitely head toward this direction. Now,展开更多
基金Acknowledgments Financial supports were provided by the National Natural Science Foundation of China （No. 90508008 and 30428030）, National Basic Research Program of China （No. 2006CB944004） and a project supported by the‘ 100 Talents Project＇ of the Chinese Academy of Sciences, China. Research of Qi Xie was supported by grant CNSF30530400 from the Chinese Natural Science Foundation.
文摘Afundamental question for meiosis is how homologous chromosomes （homologs） find each other and pair together to ensure homologous recombination and segregation. Intuitively, the answer to the question is related to the interaction between homologous sequences. However, that is not the whole story according to some studies on the role of cohesins in homolog pairing. The most recent one by Ishiguro et al. of the Watanabe group indicates that chromosome architecture defined by a meiosis-specific cohesin protein RAD21L is the key to homology searching. Moreover, they report that homologous pairing is dependent on neither SPOll, an evolutionarily conserved type 2 isomerase responsible for generating DNA double-strand breaks （DSBs）, nor SUN1, which tethers the ends of chromosomes to the nuclear envelop （NE） and facilitates chromosome movement and bouquet formation. These discoveries are quite some surprises!
文摘Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Chaible et al,2010).At pre-sent,a variety of tools act at the DNA or RNA level to enable researchers to model gene function(and thus protein)deficiency,including nucleic acid based RNA interference(EI-bashir et al.,2001),antisense oligonucleotides(Schoch and Miller,2017),and genome editing-based CRISPR-Cas9(Doudna and Charpentier,2014)strategies.However,challenges remain.
文摘Following the publication of the US National Research Council （N RC） report ＂ Toward PrecMon Medicine.＂ Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases＂ in 2011 [1], several nations have announced that their national research programs would definitely head toward this direction. Now,
