The injectable self-healing polysaccharide hydrogel was prepared by the formation of Schiff base bonds between aldehyde-modified methylcellulose(MC–CHO)and carboxymethyl chitosan(CMC).The copper sulfide nanoparticles...The injectable self-healing polysaccharide hydrogel was prepared by the formation of Schiff base bonds between aldehyde-modified methylcellulose(MC–CHO)and carboxymethyl chitosan(CMC).The copper sulfide nanoparticles(CuS NPs)and pH-sensitive doxorubicin-loaded zeolitic imidazolate frameworks nanoparticles(DOX@ZIF-8 NPs)were prepared and could be well-dispersed into the hydrogel system.The presence of CuS NPs can achieve photothermal therapy(PTT)for tumors under the irradiation of the near-infrared(NIR)laser.Moreover,CuS NPs can generate photodynamic effects under NIR irradiation,converting oxygen into toxic reactive oxygen species(ROS)and presenting efficient photodynamic therapy(PDT).The DOX@ZIF-8 NPs can be decomposed under an intracellular acidic environment and realize the controlled release of DOX.The injectable self-healing hydrogel loading Cu S and DOX@ZIF-8 NPs can achieve synergistic photothermal-photodynamic-chemo therapy for tumors and will inspire the researchers to construct a platform from hydrogel combined with multifunctional nanomaterials to realize the effective multimodal therapy for tumor.展开更多
基金the National Natural Science Foundation of China(No.82172040)。
文摘The injectable self-healing polysaccharide hydrogel was prepared by the formation of Schiff base bonds between aldehyde-modified methylcellulose(MC–CHO)and carboxymethyl chitosan(CMC).The copper sulfide nanoparticles(CuS NPs)and pH-sensitive doxorubicin-loaded zeolitic imidazolate frameworks nanoparticles(DOX@ZIF-8 NPs)were prepared and could be well-dispersed into the hydrogel system.The presence of CuS NPs can achieve photothermal therapy(PTT)for tumors under the irradiation of the near-infrared(NIR)laser.Moreover,CuS NPs can generate photodynamic effects under NIR irradiation,converting oxygen into toxic reactive oxygen species(ROS)and presenting efficient photodynamic therapy(PDT).The DOX@ZIF-8 NPs can be decomposed under an intracellular acidic environment and realize the controlled release of DOX.The injectable self-healing hydrogel loading Cu S and DOX@ZIF-8 NPs can achieve synergistic photothermal-photodynamic-chemo therapy for tumors and will inspire the researchers to construct a platform from hydrogel combined with multifunctional nanomaterials to realize the effective multimodal therapy for tumor.
