Porphyrins and their derivatives are excellent photosensitizers in photodynamic therapy(PDT).The modification of porphyrin molecules into metal-organic cages(MOCs)is a viable strategy to improve their bioavailability....Porphyrins and their derivatives are excellent photosensitizers in photodynamic therapy(PDT).The modification of porphyrin molecules into metal-organic cages(MOCs)is a viable strategy to improve their bioavailability.In this work,MOC C66 based on porphyrin was synthesised by a one-pot self-assembly method.The three-dimensional structure of the metal-organic cage ameliorated the aggregation and selfquenching of porphyrins and increased the molar absorption coefficient in the visible light region,which enhanced the reactive oxygen species(ROS)yield of porphyrins and effectively improved the efficiency of photodynamic therapy.ROS generation ability tests in solution confirmed the improved reactive oxygen capacity of the cage,which showed greater phototoxicity to HeLa and MCF-7 cells in vitro,suggesting a new strategy for future modifications of the simple synthesis of porphyrins as photosensitizers.展开更多
The design and preparation of luminescent M2L3 metal-organic cage via the coordination-driven selfassembly of carbazole-based ligand with a V-shaped geometry is described.The cage Zn-L1 with an open cavity which equip...The design and preparation of luminescent M2L3 metal-organic cage via the coordination-driven selfassembly of carbazole-based ligand with a V-shaped geometry is described.The cage Zn-L1 with an open cavity which equipped aromatic rich ligands shows the highest emission quenching efficiency towards picric acid than other nitroaromatic explosives.The quenching ability depended on whether there formed the host-guest molecules are well explored by electrospray ionization mass spectrometry(ESIMS),and isothermal titration microcalorimetry(ITC).展开更多
基金supported by the National Natural Science Foundation of China(Nos.21977015 and 21820102001).
文摘Porphyrins and their derivatives are excellent photosensitizers in photodynamic therapy(PDT).The modification of porphyrin molecules into metal-organic cages(MOCs)is a viable strategy to improve their bioavailability.In this work,MOC C66 based on porphyrin was synthesised by a one-pot self-assembly method.The three-dimensional structure of the metal-organic cage ameliorated the aggregation and selfquenching of porphyrins and increased the molar absorption coefficient in the visible light region,which enhanced the reactive oxygen species(ROS)yield of porphyrins and effectively improved the efficiency of photodynamic therapy.ROS generation ability tests in solution confirmed the improved reactive oxygen capacity of the cage,which showed greater phototoxicity to HeLa and MCF-7 cells in vitro,suggesting a new strategy for future modifications of the simple synthesis of porphyrins as photosensitizers.
基金the National Natural Science Foundation of China (Nos.21861132004 and 21701019)China Postdoctoral Science Foundation (No.2018M630286)
文摘The design and preparation of luminescent M2L3 metal-organic cage via the coordination-driven selfassembly of carbazole-based ligand with a V-shaped geometry is described.The cage Zn-L1 with an open cavity which equipped aromatic rich ligands shows the highest emission quenching efficiency towards picric acid than other nitroaromatic explosives.The quenching ability depended on whether there formed the host-guest molecules are well explored by electrospray ionization mass spectrometry(ESIMS),and isothermal titration microcalorimetry(ITC).
