The Coordinated Influence of Indian Ocean Sea Surface Temperature and Arctic Sea Ice on Anomalous Northeast China Cold Vortex Activities with Different Paths during Late Summer

The Northeast China cold vortex(NCCV)during late summer(from July to August)is identified and classified into three types in terms of its movement path using machine learning.The relationships of the three types of NCCV intensity with atmospheric circulations in late summer,the sea surface temperature(SST),and Arctic sea ice concentration(SIC)in the preceding months,are analyzed.The sensitivity tests by the Community Atmosphere Model version 5.3(CAM5.3)are used to verify the statistical results.The results show that the coordination pattern of East Asia-Pacific(EAP)and Lake Baikal high pressure forced by SST anomalies in the North Indian Ocean dipole mode(NIOD)during the preceding April and SIC anomalies in the Nansen Basin during the preceding June results in an intensity anomaly for the first type of NCCV.While the pattern of high pressure over the Urals and Okhotsk Sea and low pressure over Lake Baikal during late summer-which is forced by SST anomalies in the South Indian Ocean dipole mode(SIOD)in the preceding June and SIC anomalies in the Barents Sea in the preceding April-causes the intensity anomaly of the second type.The third type is atypical and is not analyzed in detail.Sensitivity tests,jointly forced by the SST and SIC in the preceding period,can well reproduce the observations.In contrast,the results forced separately by the SST and SIC are poor,indicating that the NCCV during late summer is likely influenced by the coordinated effects of both SST and SIC in the preceding months.

Rational design of Fe/Co-based diatomic catalysts for Li–S batteries by first-principles calculations

Fe/Co-based diatomic catalysts decorated on an N-doped graphene substrate are investigated by first-principles calculations to improve the electrochemical properties of Li–S batteries.Our results demonstrate that Fe CoN8@Gra not only possesses moderate adsorption energies towards Li2Snspecies,but also exhibits superior catalytic activity for both reduction and oxidation reactions of the sulfur cathode.Moreover,the metallic property of the diatomic catalysts can be well maintained after Li2Snadsorption,which could help the sulfur cathode to maintain high conductivity during the whole charge–discharge process.Given these exceptional properties,it is expected that Fe CoN8@Gra could be a promising diatomic catalyst for Li–S batteries and afford insights for further development of advanced Li–S batteries.

Classification of Northeast China Cold Vortex Activity Paths in Early Summer Based on K-means Clustering and Their Climate Impact

The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the atmospheric circulation field and temperature field data of ERA-Interim for every six hours,the NCCV processes during the early summer(June)seasons from 1979 to 2018 were objectively identified.Then,the NCCV processes were classified using a machine learning method(k-means)according to the characteristic parameters of the activity path information.The rationality of the classification results was verified from two aspects,as follows:(1)the atmospheric circulation configuration of the NCCV on various paths;and(2)its influences on the climate conditions in the NEC.The obtained results showed that the activity paths of the NCCV could be divided into four types according to such characteristics as the generation origin,movement direction,and movement velocity of the NCCV.These included the generation-eastward movement type in the east of the Mongolia Plateau(eastward movement type or type A);generation-southeast longdistance movement type in the upstream of the Lena River(southeast long-distance movement type or type B);generationeastward less-movement type near Lake Baikal(eastward less-movement type or type C);and the generation-southward less-movement type in eastern Siberia(southward less-movement type or type D).There were obvious differences observed in the atmospheric circulation configuration and the climate impact of the NCCV on the four above-mentioned types of paths,which indicated that the classification results were reasonable.

Synchronization of two coupled exciters in a vibrating system of spatial motion

The paper proposes an analytical approach to investigate the synchronization of the two coupled exciters in a vibrating system of spatial motion. Introducing the distur- bance parameters for average angular velocity of two excit- ers, we deduce the non-dimensional coupling equations of angular velocities of two exciters, in which the inertia cou- pling matrix is symmetric and the stiffness coupling matrix is antisymmetric in a non-resonant vibrating system. The analysis of the coupling dynamic characteristic shows that the coupled cosine effect of the phase angles will cause the torque acting on two motors to limit the increase of phase difference between two exciters as well as sustain its sym- metry of two exciters during the running process. It physi- cally explains the peculiarity of self-synchronization of two exciters. The cosine effect of phase angles of the vibrations excited by each exciter will decrease its moment of inertia. The residual moment of inertia of each exciter represents its relative moment of inertia. The stability condition of synchro- nization of two exciters is that the relative non-dimensional moments of inertia of two exciters are all greater than zero and four times their product is greater than the square of their coefficient of coupled cosine effect of phase angles, which is equivalent to that the inertia coupling matrix is positive definite and all its elements are positive. The numeric results show that the structure of the vibrating system can ensure the stability condition of synchronous operation.

Self-synchronization theory of dual motor driven vibration system with two-stage vibration isolation frame

This paper studies self-synchronization and stability of a dual-motor driven vibration system with a two-stage vibration isolation frame. Oscillation amplitude of the material box large enough can be ensured on the vibration system in order to screen materials. Reduction of the dynamic load transmitted to the foundation can also be achieved for the vibration system. A Lagrange equation is used to set up the motion differential equations of the system, and a dimensionless coupled equation of the eccentric rotors is obtained using a method of modified average small parameter. According to the existence condition of zero solution in the dimensionless coupled equation of the eccentric rotors, the precondition for commencing self-synchronization motion is achieved.The stability condition of self-synchronization is obtained based on the Routh-Hurwitz criterion. The theoretical analysis is validated by simulations and experiments.

直升机声学超材料舱壁的低频多带隙降噪特性

针对直升机舱内500 Hz以下的低频噪声控制难题,在原有直升机舱壁结构基础上引入声学超材料设计范式,提出一类低频多带隙声学超材料结构。该声学超材料结构单元内部包含4个悬臂梁式共振结构,在各个共振结构的谐振频率处能够打开局域共振完整带隙。首先,建立声学超材料结构单元的有限元动力学模型,算例分析其能带结构特性并揭示多带隙形成机理。其次,开展声学超材料样件安装于小尺寸均匀平直板前后的法向入射传声损失试验与锤击激励振声试验,发现实测的隔声提高区和传递函数幅值衰减区均符合理论预测的带隙频率范围,从而验证了理论模型的正确性。最后,在混响室-全消声室测试环境中开展声学超材料样件附加于大尺寸曲面加筋壁板前后的扩散场入射传声损失试验与激振器激励振声试验,证明即便应用于复杂结构壁板,声学超材料的带隙频段仍然显示出很高的潜力来改善隔声性能和振声行为。研究工作旨在为采用轻薄声学超材料降低直升机舱内噪声提供思路和方法。

Effects of Light and Temperature Factors on Biomass Accumulation of Winter Wheat

[Objective] The study aimed to discuss the influence of light and temperature factors on biomass accumulation of winter wheat at each growth stage and changes in biomass of each organ. [Method] Based on the observation data from Xifeng Agrometeorological Experiment Station of Gansu Province, including phenophase and yield factors of winter wheat in 1981 -2008, biomass at three-leaves, overwintering, jointing, heading, milky maturity, and maturity stages in 1995 -2008, and meteorological data in 1995 -2008, the variation patterns of the biomass accumulation and the influence of TEP （thermal effectiveness photosynthetically active radiation） on the biomass of winter wheat at every growth stage were ana- lyzed. [Result] The biomass accumulation of winter wheat in the whole growth period presented ＂S＂ curve, with the maximum value from heading to milky maturity stage. Since 1981, TEP from heading to milky maturity stage increased with a rate of 3. 314 MJ/（m2 · a）, and the changing curves of TEP at other stages were like parable curves. TEP from turning green to jointing stage and from milky maturity to maturity stage had a higher value in the 1990s and a lower val.ue in the 1980s and early 21st century, while that from jointing to heading stage had a lower value in the 1990s but a higher value in the 1980s and early 21st century. There was a significant correlation between TEP at each growth stage and the actual yield. LAI （leaf area index） at each development stage also had a significant correlation with the utilization rate of TEP at corresponding stage. When LAI at jointing and heading stages increased by I, the utilization rate of TEP correspondingly increased by 0. 049 and 0.259 g/MJ respectively. [ Conclusion] The research could provide theoretical references for the scientific planting and management of winter wheat in future. Key words Light and temperature factors; Winter wheat; Biomass; Influence; China

Risk Evaluation of Rainstorm and Flood in the Upper Reaches of Hunhe River (Qingyuan Section) Based on the FloodArea Model

By using data of hourly rainfall with all of the meteorological stations in the upper reaches of Hunhe River (Qingyuan Section), the digital elevation model, the land use and the disasters data etc., the storm flood process which happened on 16 August 2013 is reproduced simulated based on the rainstorm flooding of FloodArea model, also the flooding simulation and its effectiveness have been carried out. Conclusions are drawn as follows: there is a sharp rise of the flood depth falling behind the change of rainfall three or four hours. As the accumulation of the precipitation, the water level has increased, and when the precipitation process stops, the flood pooled into midstream and downstream gradually. According to the disaster investigation, in both the aspects of flooding scope and flooding depth of warning spots, the simulation result of FloodArea model agrees with the fact. It indicates that the FloodArea model generates good simulation effect in the upper reaches of Hunhe River (Qingyuan Section). Combined with population and GDP information, in the whole river, about eighty-three thousand people were affected by flooding, also one billion and five hundred seventy five million RMB of gross domestic product was lost. When the flood depth deepens and the flooding scope increases, correspondingly the loss rate of population and GDP rises and the flood risk increases.

Risk Assessment and Simulation on Storm Flood of the 100-Year Return Period in Hunhe River Basin

Based on the meteorological and geographic information data, with statistical method and the FloodArea model, the extreme daily rainfall of the 100-year return period in Hunhe River basin was established, through the simulation of rainstorm and flood disaster, characteristics of flood depth in warning spot Cangshi village in the upstream of the river were analysed, and possible effect on community economy was also evaluated. Results showed that, the precipitation of 100-year return period occurred, the flood depth has been below 1.0 meter in the most areas of Hunhe River basin, the depth was between 1.0 meter and 2.5 meters in the part areas of Hunhe River basin, and the flood depth has been exceed 2.5 meters in a small part of Hunhe River basin. After the beginning of precipitation, the flood was concentrated in the upper reaches of the river. With the accumulation of precipitation and the passage of time, the flood pools into midstream and downstream. Precipitation lasted for 24 hours, the warning spot was flooded in the beginning of precipitation. With the accumulation of precipitation, water level of the river increases gradually. The depth of warning spot has passed 1.0 meter at the 07 time of the whole process, and the maximum value of flood depth at warning spot was 1.083 meters that occurred at the 19 time. The flood depth of warning spot decreased gradually after the precipitation stopping, and the depth has been below 0.2 meters, the flood of upstream ended. Up to the end of the upstream flood process, in the whole river, about one million five hundred and sixty thousand people were affected by flooding, and thirty-eight billion and two hundred million RMB of gross domestic product were lost, in addition, dry land and paddy field were affected greatly, but woodland and grassland were less affected.

The Opportunity and Challenge of the Development of Artificial Intelligence to Human Labor Liberation

With the development and application of artificial intelligence(AI)technology,it has promoted the upgrading and development of the industry.However,AI also brings intangible impact to the actual survival of human beings.Stephen·Hawking,the renowned physicist,has repeatedly warned,making it all the more urgent to reflect on the negative effects of artificial intelligence.Therefore,the review of AI should consider from the perspective of historical development,scientifically explain its changes in the way of human labor and social life,as well as the great significance of such changes to the liberation of human labor.

Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

The arginine-vasopressin(AVP)hormone plays a pivotal role in regulating various physiological processes,such as hormone secretion,cardiovascular modulation,and social behavior.Recent studies have highlighted the V1a receptor as a promising therapeutic target.In-depth insights into V1a receptor-related pathologies,attained through in vivo imaging and quantification in both peripheral organs and the central nervous system(CNS),could significantly advance the development of effective V1a inhibitors.To address this need,we develop a novel V1a-targeted positron emission tomography(PET)ligand,[18F]V1A-2303([18F]8),which demonstrates favorable in vitro binding affinity and selectivity for the V1a receptor.Specific tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies,autoradiography,biodistribution assessments.Furthermore,[18F]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity,whole-body distribution,and kinetic properties.Our research indicated[18F]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs,and as a foundational element for the development of next-generation,brain-penetrant ligands specifically designed for the CNS.

Sub-Seasonal Predictability of the Northeast China Cold Vortex in BCC and ECMWF S2S Model Forecasts for 2006-2021

As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried out.Based on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal timescale.The results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the observations.Diagnostic analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S models.Nonetheless,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual members.In the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in summer.The results from this study provide helpful references for further improvement of the S2S prediction of NCCVs.

Current status of cognition and skin care behavior in adolescent patients with acne:A survey in China

To the Editor:Acne vulgaris(AV)is a common inflammatory skin condition.Population-based epidemiological studies have reported associations between dietary habits,lifestyle factors,family history,and the occurrence and development of acne.^([1–4])This study investigated the skincare behavior and cognition of patients with AV regarding predisposing factors using a designed electronic questionnaire.

Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine

Nanomedicine has become an important development direction of modern medicine, and provides a new way for cancer theranostics. To extend the superior physicochemical property of nanomedicine and enhance their role in cancer theranostics,various strategies have been proposed. Among them, the introduction of oxygen vacancies can enhance the separation of electron-hole pairs and improve the nanomaterials' catalytic activity, which is beneficial for cancer diagnosis and treatment. This review briefly summarized the formation mechanism and preparation methods of various oxygen vacancy nanomaterials. Then,the effect and application of various oxygen vacancy nanomaterials, such as iron, manganese, titanium, zinc, bismuth, tungsten,cerium, and molybdenum-based nanomaterials in enhancing cancer theranostics were highlighted. At last, the prospect and challenges of oxygen vacancy nanomaterials were discussed. This review provided an overview of the relevant information on oxygen vacancy in cancer theranostics, and further promoted the development of cancer nanomedicine.

Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PET)radioligand is currently lacking.As such,the aim of this study was to develop a suitable M4PET ligand that allows the non-invasive visualization of M4in the brain.Structure-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAM).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the M4-rich striatum.However,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric site.Remarkably,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher species.These results pointed towards significant species-differences and paved the way for a preliminary PET study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal cortex.In conclusion,we report on the identification and preclinical development of the first radiofluorinated M4PET radioligand with promising attributes.The availability of a clinically validated M4PET radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging.

Low-efficiency-droop InGaN quantum dot light-emitting diodes operating in the “green gap”

Gallium nitride(Ga N)-based light-emitting diodes(LEDs)are important for lighting and display applications.In this paper,we demonstrate green-emission(512 nm)In Ga N quantum dot(QD)LEDs grown on a c-plane sapphire substrate by metal-organic chemical vapor deposition.A radiative lifetime of 707 ps for the uniform In Ga N self-assembled QDs is obtained by time-resolved photoluminescence measurement at 18 K.The screening of the built-in fields in the QDs effectively improves the performance of QD LEDs.These high quantum efficiency and high temperature stability green QD LEDs are able to operate with negligible efficiency droop and with current density up to 106 A∕cm^2.Our results show that In Ga N QDs may be a viable option as the active medium for stable LEDs.

Multi-Scheme Corrected Dynamic–Analogue Prediction of Summer Precipitation in Northeastern China Based on BCC_CSM

Based on summer precipitation hindcasts for 1991-2013 produced by the Beijing Climate Center Climate System Model （BCC_CSM）, the relationship between precipitation prediction error in northeastern China （NEC） and global sea surface temperature is analyzed, and dynamic-analogue prediction is carried out to improve the summer precipitation prediction skill of BCC_CSM, through taking care of model historical analogue prediction error in the real-time output. Seven correction schemes such as the systematic bias correction, pure statistical correction, dynamic-analogue correction, and so on, are designed and compared. Independent hindcast results show that the 5-yr average anomaly correlation coefficient （ACC） of summer precipitation is respectively improved from -0. 13/0.15 to 0.16/0.24 for 2009-13/1991-95 when using the equally weighted dynamic-analogue correction in the BCC_CSM prediction, which takes the arithmetical mean of the correction based on regional average error and that on grid point error. In addition, probabilistic prediction using the results from the multiple correction schemes is also performed and it leads to further improved 5-yr average prediction accuracy.

Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium spiny neurons of the striatum,it has been implicated in a variety of neurological disorders.Indeed,inhibition of PDE10A has proven to be of potential use for the treatment of central nervous system(CNS)pathologies caused by dysfunction of the basal ganglia–of which the striatum constitutes the largest component.A PDE10A-targeted positron emission tomography(PET)radioligand would enable a better assessment of the pathophysiologic role of PDE10A,as well as confirm the relationship between target occupancy and administrated dose of a given drug candidate,thus accelerating the development of effective PDE10A inhibitors.In this study,we designed and synthesized a novel ^(18)F-aryl PDE10A PET radioligand,codenamed[^(18)F]P10A-1910([^(18)F]9),in high radiochemical yield and molar activity via spirocyclic iodonium ylide-mediated radiofluorination.[^(18)F]9 possessed good in vitro binding affinity(IC_(50)=2.1 nmol/L)and selectivity towards PDE10A.Further,[^(18)F]9 exhibited reasonable lipophilicity(logD=3.50)and brain permeability(P_(app)>10×10^(−6) cm/s in MDCK-MDR1 cells).PET imaging studies of[^(18)F]9 revealed high striatal uptake and excellent in vivo specificity with reversible tracer kinetics.Preclinical studies in rodents revealed an improved plasma and brain stability of[^(18)F]9 when compared to the current reference standard for PDE10A-targeted PET,[^(18)F]MNI659.Further,dose–response experiments with a series of escalating doses of PDE10A inhibitor 1 in rhesus monkey brains confirmed the utility of[^(18)F]9 for evaluating target occupancy in vivo in higher species.In conclusion,our results indicated that[^(18)F]9 is a promising PDE10A PET radioligand for clinical translation.

Bias Analysis and Correction of Ground Surface Temperature Observations across China

Based on the ground surface temperature(GST)and snow surface temperature(SST)measurements during the period of adjustment from manual to automatic observation systems in China,the influence of observation methods on GST and its relationship with snow cover is analyzed.GST is corrected by SST,and the correction effect is evaluated.The results show that,during the parallel observation period,the winter GSTs from automatic observations are generally higher than those from manual observations,with the automatically observed national daily GST 1.18°C higher.The adjustment has a greater impact on GSTs at 0200,0800,and 2000 Beijing Time(BT)than at 1400 BT,and it has the greatest impact in Northeast and Northwest China,with deviations of 5.24 and 2.09°C,respectively.The GST deviation is closely related to the snow depth and annual snow totals.The average daily GST deviation increases at the rate of 0.66°C per 1-cm increase of snow depth when it is<15 cm,while it tends to be stable at around 10°C for snow depth over 15 cm.The GST deviation at a station is affected by its winter snow totals in Northeast and Northwest China,where the largest deviations are found where snow totals are all above 1000 cm.After the correction with SST,the mean deviation between the automatic and manual observations as well as the false trend can be effectively reduced.Following the correction,the mean deviation of daily GST decreases by 5.8°C,and its trend decreases from 1.87 to 0.65°C decade-1.

Life-Inspired Endogenous Dynamic Behavior of Lipid Droplet-like Microcompartments in Artificial Adipocyte-like Structures

Chemical systems that can replicate cellular behaviors are gaining increasing attention and are being used to study various biological processes.Here,a protein-or amylose-based assembly at an oil/water interface was employed to construct a large compartmentalized adipocyte-like structure,and a lipid droplet-like microcompartment(amylose-polymerstabilized 2-ethyl-1-hexanol microcompartment),which exhibits floating behaviors driven by the amylose-polymer micelle solubilization,was introduced inside these adipocyte-like structures.When the lipase-based catalytic reaction and the external oil composition were controlled and another lipid droplet-like microcompartment(lipase-stabilized tributyrin microcompartment)was introduced,then a series of dynamic behaviors were exhibited by the two types of lipid droplet-like microcompartments,including growth,self-sorting,and fusion within the adipocyte-like structures.Therefore,it is anticipated that this autonomous generation of hierarchical multicompartments represents a breakthrough compared to the traditional bottom-up strategies,and the artificial life systems we studied could contribute a chemical-based strategy of understanding the process of lipid droplet growth and fusion inside a living adipocyte cell.