Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However,the precise molecular mechanisms linking mitochondrial damage to kidney disease rem...Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive.The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal diseases.One of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING pathway.Herein,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases.Furthermore,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney diseases.This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.展开更多
基金supported by a grant from the Zhejiang Provincial Natural Science Foundation of China(No.LY22H050002)
文摘Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive.The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal diseases.One of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING pathway.Herein,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases.Furthermore,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney diseases.This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.
