期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system
1
作者 Qiran Chen Wei Sun +3 位作者 Lin Jin Yingjie Zhou Fang Li chutian ge 《Zoological Research》 SCIE 2024年第5期1108-1115,共8页
In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to dif... In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to differentiation into either testes or ovaries,is governed by the finely tuned expression of upstream genes,notably the testis-promoting gene Dmrt1 and the ovary-promoting gene Foxl2.Recent studies have identified epigenetic regulation as a crucial factor in testis development,with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in T.s.elegans.However,whether KDM6B alone can induce testicular differentiation remains unclear.In this study,we found that overexpression of Kdm6b in T.s.elegans embryos induced the male development pathway,accompanied by a rapid increase in the gonadal expression of Dmrt1 at 31°C,a temperature typically resulting in female development.Notably,this sex reversal could be entirely rescued by Dmrt1 knockdown.These findings demonstrate that Kdm6b is sufficient for commitment to the male pathway,underscoring its role as a critical epigenetic regulator in the sex determination of the red-eared slider turtle. 展开更多
关键词 Temperature-dependent sex determination Sex reversal Kdm6b Dmrt1 T.s.elegans
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部