In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical trials.Organoids are essentially mi...In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical trials.Organoids are essentially miniature 3D models of specific organs or tissues,enabling scientists to investigate the causes of diseases,test new drugs,and explore personalized medicine within a controlled laboratory setting.Over the past decade,organoid technology has made substantial progress,allowing researchers to create highly detailed environments that closely mimic the human body.These organoids can be generated from various sources,including pluripotent stem cells,specialized tissue cells,and tumor tissue cells.This versatility enables scientists to replicate a wide range of diseases affecting different organ systems,effectively creating disease replicas in a laboratory dish.This exciting capability has provided us with unprecedented insights into the progression of diseases and how we can develop improved treatments.In this paper,we will provide an overview of the progress made in utilizing organoids as preclinical models,aiding our understanding and providing a more effective approach to addressing various human diseases.展开更多
基金supported by the National Key Research and Development Program of China(2022YFA1103800,2023YFE0210100,and 2019YFA0904500)the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB0480000)+8 种基金the National Natural Science Foundation Projects of China(92157202,32025010,32241002,92254301,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,and 32300620)the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003)the International Cooperation Program,CAS(154144KYSB20200006)the CAS Project for Young Scientists in Basic Research(YSBR-075)the Guangdong Province Science and Technology Program(2023B1111050005,2023A1515030231,2022A1515110493,2020B1212060052,2021A1515012513,2021B1515020096,2022A1515012616,2022A1515110951,2023B1212120009)the Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,202206060002 and 2023A04J0414)the CAS Youth Innovation Promotion Association(Y2021097 and 2021355)NSFC/RGC Joint Grant Scheme(N_CUHK 428/22)and the open research funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital(202301-203).
文摘In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical trials.Organoids are essentially miniature 3D models of specific organs or tissues,enabling scientists to investigate the causes of diseases,test new drugs,and explore personalized medicine within a controlled laboratory setting.Over the past decade,organoid technology has made substantial progress,allowing researchers to create highly detailed environments that closely mimic the human body.These organoids can be generated from various sources,including pluripotent stem cells,specialized tissue cells,and tumor tissue cells.This versatility enables scientists to replicate a wide range of diseases affecting different organ systems,effectively creating disease replicas in a laboratory dish.This exciting capability has provided us with unprecedented insights into the progression of diseases and how we can develop improved treatments.In this paper,we will provide an overview of the progress made in utilizing organoids as preclinical models,aiding our understanding and providing a more effective approach to addressing various human diseases.
