Cancer remains the second leading cause of death worldwide and a major public health and economic issue.To reduce the burden,new approaches are necessary to diagnose the disease at early stages and improve clinical ou...Cancer remains the second leading cause of death worldwide and a major public health and economic issue.To reduce the burden,new approaches are necessary to diagnose the disease at early stages and improve clinical outcomes of cancer patients,for which understanding the molecular mechanisms of carcinogenesis is crucial.Autophagy is a pro-survival pathway that ensures the removal and renewal of cellular macromolecular structures,thus playing a crucial role in the maintenance of cellular homeostasis.Dysregulation of autophagy can favor chemoresistance and survival of dormant cancer cells,thus favoring cancer progression and relapse.Several studies report dysregulated expression of long non-coding RNAs and micro-RNAs acting as tumor suppressors or tumor promoters by targeting genes involved in the autophagy pathway.Here,we focus on the role played by non-coding RNAs-mediated regulation of autophagy in development and progression of cancers in women.Understanding how epigenetics can impact autophagy might open novel therapeutic strategies in the fight against cancers in women.展开更多
Cancer remains a leading cause of death, despite the undeniable progress made in the last decades in thediagnosis and therapeutic treatments. Further improvements are only possible if we understand morein depth how ca...Cancer remains a leading cause of death, despite the undeniable progress made in the last decades in thediagnosis and therapeutic treatments. Further improvements are only possible if we understand morein depth how cancer develops and metastasizes, and how it produces its damaging effects on the wholeorganisms, including immune-suppression and cachexia, that eventually lead to patient death. The goal ofthe International Workshop No-Cancer 2018 “understanding cancer cell biology to improve diagnosis andtherapy” held in 28-30 Oct, in Novara (Italy) is precisely to share the foremost updated knowledge on thebiology of cancer and the emerging technologies for early detection of cancer cells and the new “chemo-free”therapeutic options.展开更多
文摘Cancer remains the second leading cause of death worldwide and a major public health and economic issue.To reduce the burden,new approaches are necessary to diagnose the disease at early stages and improve clinical outcomes of cancer patients,for which understanding the molecular mechanisms of carcinogenesis is crucial.Autophagy is a pro-survival pathway that ensures the removal and renewal of cellular macromolecular structures,thus playing a crucial role in the maintenance of cellular homeostasis.Dysregulation of autophagy can favor chemoresistance and survival of dormant cancer cells,thus favoring cancer progression and relapse.Several studies report dysregulated expression of long non-coding RNAs and micro-RNAs acting as tumor suppressors or tumor promoters by targeting genes involved in the autophagy pathway.Here,we focus on the role played by non-coding RNAs-mediated regulation of autophagy in development and progression of cancers in women.Understanding how epigenetics can impact autophagy might open novel therapeutic strategies in the fight against cancers in women.
文摘Cancer remains a leading cause of death, despite the undeniable progress made in the last decades in thediagnosis and therapeutic treatments. Further improvements are only possible if we understand morein depth how cancer develops and metastasizes, and how it produces its damaging effects on the wholeorganisms, including immune-suppression and cachexia, that eventually lead to patient death. The goal ofthe International Workshop No-Cancer 2018 “understanding cancer cell biology to improve diagnosis andtherapy” held in 28-30 Oct, in Novara (Italy) is precisely to share the foremost updated knowledge on thebiology of cancer and the emerging technologies for early detection of cancer cells and the new “chemo-free”therapeutic options.
