Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were fou...Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K1 prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K1 concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥0.2 mg vitamin K1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.展开更多
A 48-year-old airline mechanic from Belize presented to the emergency depart ment with fever and altered mental status. Two weeks earlier, fever, myalgias, a nd dry cough had developed. His maximal daily temperature r...A 48-year-old airline mechanic from Belize presented to the emergency depart ment with fever and altered mental status. Two weeks earlier, fever, myalgias, a nd dry cough had developed. His maximal daily temperature reached as high as 41. 1°C, and one week before coming to the emergency department, the patient awaken ed unable to speak. At a hospital in Belize, he was febrile and aphasic without other focal neurologic findings. The results of computed tomography (CT) of the brain were normal. Examination of the cerebrospinal fluid revealed a protein lev el of 157 mg per deciliter and a glucose level of 44 mg per deciliter (2.4 mmol per liter) but no cells or microorganisms. The patient rec eived treatment with chloroquine and acyclovir for the next five days but did no t improve and was flown to Chicago for further care. On examination, the patient was agitated and unable to speak or follow verbal commands. The blood pressure was 132/74 mm Hg, the pulse 82 beats per minute, and the respiratory rate 20 bre aths per minute. The temperature was 39.5°C. The results of the general examina tion were normal, without meningismus. A neurologic examination revealed global aphasia but was otherwise normal except for an equivocal extensor plantar respon se on the right. The optic fundi appeared normal.展开更多
文摘Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K1 prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K1 concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥0.2 mg vitamin K1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.
文摘A 48-year-old airline mechanic from Belize presented to the emergency depart ment with fever and altered mental status. Two weeks earlier, fever, myalgias, a nd dry cough had developed. His maximal daily temperature reached as high as 41. 1°C, and one week before coming to the emergency department, the patient awaken ed unable to speak. At a hospital in Belize, he was febrile and aphasic without other focal neurologic findings. The results of computed tomography (CT) of the brain were normal. Examination of the cerebrospinal fluid revealed a protein lev el of 157 mg per deciliter and a glucose level of 44 mg per deciliter (2.4 mmol per liter) but no cells or microorganisms. The patient rec eived treatment with chloroquine and acyclovir for the next five days but did no t improve and was flown to Chicago for further care. On examination, the patient was agitated and unable to speak or follow verbal commands. The blood pressure was 132/74 mm Hg, the pulse 82 beats per minute, and the respiratory rate 20 bre aths per minute. The temperature was 39.5°C. The results of the general examina tion were normal, without meningismus. A neurologic examination revealed global aphasia but was otherwise normal except for an equivocal extensor plantar respon se on the right. The optic fundi appeared normal.
