期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Quality of life 10 years after liver transplantation:The impact of graft histology 被引量:1
1
作者 Vincent Karam Mylène Sebagh +8 位作者 Kinan Rifai Funda Yilmaz Prashant Bhangui colette danet Faouzi Saliba Didier Samuel Denis Castaing René Adam Cyrille Feray 《World Journal of Transplantation》 2016年第4期703-711,共9页
AIM To evaluate the relationship between the state of transplanted liver graft and the recipient quality of life(QOL) of histologically proven lesions in a 10-year post liver transplantation(LT) cohort of patients. ME... AIM To evaluate the relationship between the state of transplanted liver graft and the recipient quality of life(QOL) of histologically proven lesions in a 10-year post liver transplantation(LT) cohort of patients. METHODS Seventy-two recipients with a functional first graft at 10 years post-LT underwent liver biopsy and completed a QOL questionnaire. Logistic regression analysis was used to explore associations between histological, clinical andQOL criteria. RESULTS Ten years after LT, fibrosis was detected in 53% of patients, and affected the general health perception, while ductopenia, present in 36%, affected the well-being(P = 0.05). Hepatic steatosis(HS) was present in 33% of patients and was associated with the worst QOL score on multiple domains. When compared to patients without HS, patients with HS had significantly higher incidence of fibrosis(P = 0.03), hepatitis C virus(HCV) infection(P = 0.007), and more patients had retired from their job(P = 0.03). Recurrent or de novo HCV-associated fibrosis and patient retirement as objective variables, and abdominal pain or discomfort and joint aches or pains as subjective variables, emerged as independent determinants of HS. CONCLUSION Long-term liver graft lesions, mainly HS presumably as a surrogate marker of HCV infection, may have a substantial impact on QOL 10 years after LT. 展开更多
关键词 Liver transplantation Quality of life Liver biopsy Hepatic steatosis Liver fibrosis
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部