Autoantibodies targeting neuronal membrane proteins can cause encephalitis,seizures,and severe behavioral abnormalities.While antibodies for several neuronal targets have been identified,structural details on how they...Autoantibodies targeting neuronal membrane proteins can cause encephalitis,seizures,and severe behavioral abnormalities.While antibodies for several neuronal targets have been identified,structural details on how they regulate function are unknown.Here we determined cryo-electron microscopy structures of antibodies derived from an encephalitis patient bound to theγ-aminobutyric acid type A(GABAA)receptor.展开更多
文摘Autoantibodies targeting neuronal membrane proteins can cause encephalitis,seizures,and severe behavioral abnormalities.While antibodies for several neuronal targets have been identified,structural details on how they regulate function are unknown.Here we determined cryo-electron microscopy structures of antibodies derived from an encephalitis patient bound to theγ-aminobutyric acid type A(GABAA)receptor.
