In a recent article published in Nature,1 Deng and colleagues uncovered a single-molecule mechanism for protection against the harmful human microbial pathogen Streptococcus pyrogenes.The Gram-positive Group A Strepto...In a recent article published in Nature,1 Deng and colleagues uncovered a single-molecule mechanism for protection against the harmful human microbial pathogen Streptococcus pyrogenes.The Gram-positive Group A Streptococci(GAS)are responsible for a variety of acute infections ranging from noninvasive,mildly progressive to invasive infectious diseases with high mortality rates.GAS virulence factors thereby condition the invasion of the bloodstream and soft tissue,leading to invasive systemic dissemination.2 Deng et al.identified GSDMA not only as a sensor for intracellular streptopain(SpeB),an important GAS virulence factor,but also as an effector protein for host epithelial cell pyroptosis.展开更多
文摘In a recent article published in Nature,1 Deng and colleagues uncovered a single-molecule mechanism for protection against the harmful human microbial pathogen Streptococcus pyrogenes.The Gram-positive Group A Streptococci(GAS)are responsible for a variety of acute infections ranging from noninvasive,mildly progressive to invasive infectious diseases with high mortality rates.GAS virulence factors thereby condition the invasion of the bloodstream and soft tissue,leading to invasive systemic dissemination.2 Deng et al.identified GSDMA not only as a sensor for intracellular streptopain(SpeB),an important GAS virulence factor,but also as an effector protein for host epithelial cell pyroptosis.
