Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions,yielding a series of highly substituted 4-piperidones.Among the possible diastereomers,only one diastereomer was iso...Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions,yielding a series of highly substituted 4-piperidones.Among the possible diastereomers,only one diastereomer was isolated,which could be ascribed to the chair-like transition state in six-membered ring,in which all of the hindered groups are located in the pseudoequatorial orientation.展开更多
基金NSFC(No21002079)and Project(No20096203120002)supported by the Ministry of Education of the People's Republic of ChinaTechnological Innovation Project(NosNWNU-KJCXGC-03-75 and NWNU-KJCXGC-03-64) of Northwest Normal University for supporting our research
文摘Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions,yielding a series of highly substituted 4-piperidones.Among the possible diastereomers,only one diastereomer was isolated,which could be ascribed to the chair-like transition state in six-membered ring,in which all of the hindered groups are located in the pseudoequatorial orientation.
