Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer ...Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer cycles as the study group and 97 euploid embryo transfer cycles as the control group after propensity score matching, which were performed in the reproductive medicine center of the Sixth Affiliated Hospital, Sun Yat-sen University, from March 2019 to September 2023. The biopsy cells from blastocyst were undertaken next generation sequencing (NGS). Results: No significant difference in pregnancy outcomes compared between the two groups. According to the size of aneuploid, fragment the level of mosaicism or blastocyst morphological gradings, there were no significant difference in mosaic embryo transfers. Conclusion: Mosaic embryo detected in the PGT cycle can lead to clinical pregnancy and live birth of healthy offspring, which can be considerate suitable for transfer.展开更多
目的系统评价水中运动治疗对脑卒中患者下肢运动功能及日常生活活动能力的干预效果。方法检索Cochrane Library、PEDro、PubMed、EMBASE、Web of Knowledge、Web of Science、OVID、EBSCO、CMCI、CNKI、Wanfang和VIP数据库,筛选脑卒中...目的系统评价水中运动治疗对脑卒中患者下肢运动功能及日常生活活动能力的干预效果。方法检索Cochrane Library、PEDro、PubMed、EMBASE、Web of Knowledge、Web of Science、OVID、EBSCO、CMCI、CNKI、Wanfang和VIP数据库,筛选脑卒中患者水中运动治疗的随机对照试验(RCTs),进行方法学质量评价,提取相关数据,采用RevMan5.3软件进行Meta分析。结果最终纳入23项RCTs,共861例患者。与对照组相比,水中运动治疗可改善患者Berg平衡量表评分(WMD=4.61,95%CI 3.79~5.43,P<0.001)、计时起立-行走测试成绩(WMD=-1.56,95%CI-3.07^-0.05,P<0.05)、功能性前伸测试成绩(WMD=2.69,95%CI 1.21~4.16,P<0.001)、压力中心移动速度(左右)(WMD=-1.38,95%CI-2.72^-0.05,P<0.05)、压力中心移动速度(前后)(WMD=-1.64,95%CI-3.10^-0.18,P<0.05)、步速(SMD=0.33,95%CI 0.07~0.58,P<0.05)、2分钟步行测试成绩(WMD=12.75,95%CI 4.17~21.34,P<0.01)、功能性步行量表分级(WMD=0.94,95%CI 0.67~1.20,P<0.001)、膝关节伸肌肌力(WMD=4.30,95%CI 1.53~7.07,P<0.01)、膝关节屈肌肌力(WMD=4.80,95%CI 0.29~9.32,P<0.05)和功能独立性测试评分(WMD=6.12,95%CI3.98~8.27,P<0.001),但对改良Barthel指数评分无明显改善作用(WMD=2.92,95%CI-6.74~12.58,P=0.55)。结论水中运动治疗能够改善脑卒中患者的平衡功能、步行能力和下肢肌力,但对日常生活活动能力的效果不明显。展开更多
目的探索移动医疗技术在脊髓损伤患者水中康复评定中的应用价值。方法 2017年11月至2018年4月,接受水中运动治疗的脊髓损伤患者72例随机分为对照组(n=36)和实验组(n=36),采用Alyn水中适应性评定量表进行评定。对照组采用纸质评定法,实...目的探索移动医疗技术在脊髓损伤患者水中康复评定中的应用价值。方法 2017年11月至2018年4月,接受水中运动治疗的脊髓损伤患者72例随机分为对照组(n=36)和实验组(n=36),采用Alyn水中适应性评定量表进行评定。对照组采用纸质评定法,实验组采用移动应用程序法,评定2次。记录评定耗时和查询评定结果耗时,统计算分正确率,计算两次评分的变化值和变化率。结果实验组评定耗时和查询评定结果耗时均显著小于对照组(t> 10.492, P <0.001),百分制总分、总分变化率、百分制总分变化率的正确率均高于对照组(χ2> 4.545, P <0.05)。结论与传统纸质量表评定法相比,基于移动技术的电子化康复评定有助于提高工作效率。展开更多
目的运用世界卫生组织国际健康分类家族的理论架构和方法,系统评价水中运动治疗对脑瘫儿童青少年运动功能及生活质量的干预效果。方法检索Cochrane Library、PEDro、PubMed、Embase、Web of Knowledge、Web of Science、OVID、EBSCO、...目的运用世界卫生组织国际健康分类家族的理论架构和方法,系统评价水中运动治疗对脑瘫儿童青少年运动功能及生活质量的干预效果。方法检索Cochrane Library、PEDro、PubMed、Embase、Web of Knowledge、Web of Science、OVID、EBSCO、中国生物医学期刊引文数据库、中国知网期刊全文数据库、万方数据知识服务平台、维普中文期刊全文数据库建库至2020年5月,筛选水中运动治疗应用于脑瘫儿童青少年的随机对照试验,进行方法学质量评价,提取相关数据,采用RevMan 5.3软件进行Meta分析。结果最终纳入9项研究,共162例。水中运动治疗能显著改善脑瘫儿童青少年的粗大运动功能测试量表评分(WMD=6.31,95%CI 2.57~10.06,P<0.001),对日常生活活动和生活质量也有改善作用。结论水中运动治疗有助于改善脑瘫儿童青少年的运动功能和活动,并可能改善其生活质量。展开更多
As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer cycles.We aim to assess the prognostic effect of ...As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer cycles.We aim to assess the prognostic effect of baseline AMH on clinical outcomes,especially live birth rate in freezing-all embryo transfer cycles.A total of 828 non-polycystic ovary patients that underwent their first frozen-thawed embryo transfers in our center between January 2010 and January 2015 were recruited in this retrospective analysis.Patients were stratified into three groups based on their baseline AMH concentration:low AMH group (<1.4ng/mL),middle AMH group (1.4-5.8 ng/mL)and high AMH group (>5.8 ng/mL).The results showed that low AMH level was associated With adverse clinical outcomes.The differences in implantation rate (21.9% vs.43.2% vs.58.8%,P<0.001),clinical pregnancy rate (32.0% vs.55.2% vs.65.7%, P<0.001),live birth delivery rate (21.8% vs.43.6% vs.52.7%,P<0.001)and miscarriage rate (31.8% vs.17.5% vs.15.4%,P=0.014)among the three groups were statistically significant.After adjusting confounders (i.e.age,baseline FSH level,AFC,endometrium thickness,endometriurn preparation protocols,number of embryos transferred,etiologies of infertility),differences in live birth rate,clinical pregnancy rate and implantation rate between groups remained significant.The further age subgroup analysis demonstrated that low AMH concentration was significantly associated with poor outcomes both in young and advanced patients.The area under the curve for serum AMH,age,AFC and FSH were 0.635,0.634,0.615 and 0.543 respectively,for predicting live birth.In conclusion, baseline AMH was an independent prognostic factor of live birth rate of freezing-all embryo transfers,but its predictive value on live birth rate was of limited clinical value.展开更多
文摘Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer cycles as the study group and 97 euploid embryo transfer cycles as the control group after propensity score matching, which were performed in the reproductive medicine center of the Sixth Affiliated Hospital, Sun Yat-sen University, from March 2019 to September 2023. The biopsy cells from blastocyst were undertaken next generation sequencing (NGS). Results: No significant difference in pregnancy outcomes compared between the two groups. According to the size of aneuploid, fragment the level of mosaicism or blastocyst morphological gradings, there were no significant difference in mosaic embryo transfers. Conclusion: Mosaic embryo detected in the PGT cycle can lead to clinical pregnancy and live birth of healthy offspring, which can be considerate suitable for transfer.
文摘目的探索移动医疗技术在脊髓损伤患者水中康复评定中的应用价值。方法 2017年11月至2018年4月,接受水中运动治疗的脊髓损伤患者72例随机分为对照组(n=36)和实验组(n=36),采用Alyn水中适应性评定量表进行评定。对照组采用纸质评定法,实验组采用移动应用程序法,评定2次。记录评定耗时和查询评定结果耗时,统计算分正确率,计算两次评分的变化值和变化率。结果实验组评定耗时和查询评定结果耗时均显著小于对照组(t> 10.492, P <0.001),百分制总分、总分变化率、百分制总分变化率的正确率均高于对照组(χ2> 4.545, P <0.05)。结论与传统纸质量表评定法相比,基于移动技术的电子化康复评定有助于提高工作效率。
文摘目的运用世界卫生组织国际健康分类家族的理论架构和方法,系统评价水中运动治疗对脑瘫儿童青少年运动功能及生活质量的干预效果。方法检索Cochrane Library、PEDro、PubMed、Embase、Web of Knowledge、Web of Science、OVID、EBSCO、中国生物医学期刊引文数据库、中国知网期刊全文数据库、万方数据知识服务平台、维普中文期刊全文数据库建库至2020年5月,筛选水中运动治疗应用于脑瘫儿童青少年的随机对照试验,进行方法学质量评价,提取相关数据,采用RevMan 5.3软件进行Meta分析。结果最终纳入9项研究,共162例。水中运动治疗能显著改善脑瘫儿童青少年的粗大运动功能测试量表评分(WMD=6.31,95%CI 2.57~10.06,P<0.001),对日常生活活动和生活质量也有改善作用。结论水中运动治疗有助于改善脑瘫儿童青少年的运动功能和活动,并可能改善其生活质量。
文摘As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer cycles.We aim to assess the prognostic effect of baseline AMH on clinical outcomes,especially live birth rate in freezing-all embryo transfer cycles.A total of 828 non-polycystic ovary patients that underwent their first frozen-thawed embryo transfers in our center between January 2010 and January 2015 were recruited in this retrospective analysis.Patients were stratified into three groups based on their baseline AMH concentration:low AMH group (<1.4ng/mL),middle AMH group (1.4-5.8 ng/mL)and high AMH group (>5.8 ng/mL).The results showed that low AMH level was associated With adverse clinical outcomes.The differences in implantation rate (21.9% vs.43.2% vs.58.8%,P<0.001),clinical pregnancy rate (32.0% vs.55.2% vs.65.7%, P<0.001),live birth delivery rate (21.8% vs.43.6% vs.52.7%,P<0.001)and miscarriage rate (31.8% vs.17.5% vs.15.4%,P=0.014)among the three groups were statistically significant.After adjusting confounders (i.e.age,baseline FSH level,AFC,endometrium thickness,endometriurn preparation protocols,number of embryos transferred,etiologies of infertility),differences in live birth rate,clinical pregnancy rate and implantation rate between groups remained significant.The further age subgroup analysis demonstrated that low AMH concentration was significantly associated with poor outcomes both in young and advanced patients.The area under the curve for serum AMH,age,AFC and FSH were 0.635,0.634,0.615 and 0.543 respectively,for predicting live birth.In conclusion, baseline AMH was an independent prognostic factor of live birth rate of freezing-all embryo transfers,but its predictive value on live birth rate was of limited clinical value.
