Hypoxic-ischemic encephalopathy(HIE) is a disease that occurs when the brain is subjected to hypoxia,resulting in neuronal death and neurological deficits,with a poor prognosis.The mechanisms underlying hypoxic-ischem...Hypoxic-ischemic encephalopathy(HIE) is a disease that occurs when the brain is subjected to hypoxia,resulting in neuronal death and neurological deficits,with a poor prognosis.The mechanisms underlying hypoxic-ischemic brain injury include excitatory amino acid release,cellular proteolysis,reactive oxygen species generation,nitric oxide synthesis,and inflammation.The molecular and cellular changes in HIE include protein misfolding,aggregation,and destruction of organelles.The apoptotic pathways activated by ischemia and hypoxia include the mitochondrial pathway,the extrinsic Fas receptor pathway,and the endoplasmic reticulum stress-induced pathway.Numerous treatments for hypoxic-ischemic brain injury caused by HIE have been developed over the last half century.Hypothermia,xenon gas treatment,the use of melatonin and erythropoietin,and hypoxic-ischemic preconditioning have proven effective in HIE patients.Molecular chaperones are proteins ubiquitously present in both prokaryotes and eukaryotes.A large number of molecular chaperones are induced after brain ischemia and hypoxia,among which the heat shock proteins are the most important.Heat shock proteins not only maintain protein homeostasis; they also exert anti-apoptotic effects.Heat shock proteins maintain protein homeostasis by helping to transport proteins to their target destinations,assisting in the proper folding of newly synthesized polypeptides,regulating the degradation of misfolded proteins,inhibiting the aggregation of proteins,and by controlling the refolding of misfolded proteins.In addition,heat shock proteins exert anti-apoptotic effects by interacting with various signaling pathways to block the activation of downstream effectors in numerous apoptotic pathways,including the intrinsic pathway,the endoplasmic reticulum-stress mediated pathway and the extrinsic Fas receptor pathway.Molecular chaperones play a key role in neuroprotection in HIE.In this review,we provide an overview of the mechanisms of HIE and discuss the various treatment strategies.Given their critical role in the disease,molecular chaperones are promising therapeutic targets for HIE.展开更多
国家基因库生命大数据平台(China National GeneBank DataBase,CNGBdb)是一个致力于生命科学多组学数据归档和开放共享的数据库平台,是深圳国家基因库的核心功能“三库两平台”中生物信息数据库的对外服务平台,拥有深圳国家基因库丰富...国家基因库生命大数据平台(China National GeneBank DataBase,CNGBdb)是一个致力于生命科学多组学数据归档和开放共享的数据库平台,是深圳国家基因库的核心功能“三库两平台”中生物信息数据库的对外服务平台,拥有深圳国家基因库丰富的样本资源、数据资源、合作项目资源和强大的数据计算和分析能力等优势。生命科学研究已经进入到了一个以高通量多组学数据为基础的大数据时代,迫切需要加强国际合作和信息共享。随着中国经济的发展和在生命科学研究领域的研究项目投入力度的加大,需要建立相关的生命大数据归档和共享的平台,来促进我国生命科学研究项目中生成的基因组学数据的系统管理、开放共享与合理利用。目前,CNGBdb主要提供生命科学研究相关的数据归档、知识搜索、数据管理、数据计算和数据服务等服务。其归档和共享的数据类型,主要包括项目、样本、实验、测序、组装、变异、序列等。截止2020年5月22号,CNGBdb已接受了全球生命科学科研工作者提交的研究项目达2176个,归档的基因组学数据量超过2221 TB。未来,CNGBdb将继续推动生命科学研究多组学数据的开放共享和产业应用,完善基因组学数据的归档和共享功能,提升其服务生命科学数据开放共享的能力。CNGBdb的网址是:https://db.cngb.org/。展开更多
文摘Hypoxic-ischemic encephalopathy(HIE) is a disease that occurs when the brain is subjected to hypoxia,resulting in neuronal death and neurological deficits,with a poor prognosis.The mechanisms underlying hypoxic-ischemic brain injury include excitatory amino acid release,cellular proteolysis,reactive oxygen species generation,nitric oxide synthesis,and inflammation.The molecular and cellular changes in HIE include protein misfolding,aggregation,and destruction of organelles.The apoptotic pathways activated by ischemia and hypoxia include the mitochondrial pathway,the extrinsic Fas receptor pathway,and the endoplasmic reticulum stress-induced pathway.Numerous treatments for hypoxic-ischemic brain injury caused by HIE have been developed over the last half century.Hypothermia,xenon gas treatment,the use of melatonin and erythropoietin,and hypoxic-ischemic preconditioning have proven effective in HIE patients.Molecular chaperones are proteins ubiquitously present in both prokaryotes and eukaryotes.A large number of molecular chaperones are induced after brain ischemia and hypoxia,among which the heat shock proteins are the most important.Heat shock proteins not only maintain protein homeostasis; they also exert anti-apoptotic effects.Heat shock proteins maintain protein homeostasis by helping to transport proteins to their target destinations,assisting in the proper folding of newly synthesized polypeptides,regulating the degradation of misfolded proteins,inhibiting the aggregation of proteins,and by controlling the refolding of misfolded proteins.In addition,heat shock proteins exert anti-apoptotic effects by interacting with various signaling pathways to block the activation of downstream effectors in numerous apoptotic pathways,including the intrinsic pathway,the endoplasmic reticulum-stress mediated pathway and the extrinsic Fas receptor pathway.Molecular chaperones play a key role in neuroprotection in HIE.In this review,we provide an overview of the mechanisms of HIE and discuss the various treatment strategies.Given their critical role in the disease,molecular chaperones are promising therapeutic targets for HIE.
文摘国家基因库生命大数据平台(China National GeneBank DataBase,CNGBdb)是一个致力于生命科学多组学数据归档和开放共享的数据库平台,是深圳国家基因库的核心功能“三库两平台”中生物信息数据库的对外服务平台,拥有深圳国家基因库丰富的样本资源、数据资源、合作项目资源和强大的数据计算和分析能力等优势。生命科学研究已经进入到了一个以高通量多组学数据为基础的大数据时代,迫切需要加强国际合作和信息共享。随着中国经济的发展和在生命科学研究领域的研究项目投入力度的加大,需要建立相关的生命大数据归档和共享的平台,来促进我国生命科学研究项目中生成的基因组学数据的系统管理、开放共享与合理利用。目前,CNGBdb主要提供生命科学研究相关的数据归档、知识搜索、数据管理、数据计算和数据服务等服务。其归档和共享的数据类型,主要包括项目、样本、实验、测序、组装、变异、序列等。截止2020年5月22号,CNGBdb已接受了全球生命科学科研工作者提交的研究项目达2176个,归档的基因组学数据量超过2221 TB。未来,CNGBdb将继续推动生命科学研究多组学数据的开放共享和产业应用,完善基因组学数据的归档和共享功能,提升其服务生命科学数据开放共享的能力。CNGBdb的网址是:https://db.cngb.org/。
