Objective:To investigate the effect of tironon on inflammatory factors, endothelial function and cardiac function after interventional therapy in AMI patients.Methods:A total of 120 patients with acute myocardial infa...Objective:To investigate the effect of tironon on inflammatory factors, endothelial function and cardiac function after interventional therapy in AMI patients.Methods:A total of 120 patients with acute myocardial infarction in our hospital were selected as the research objects, all of them were in line with the indications of PCI operation. They were randomly divided into the observation group (60 cases) and the control group (60 cases). The control group was treated with aspirin and clopidogrel before and after PCI, and the observation group was treated with based on the use of tirofiban. Inflammatory factors, endothelial function and cardiac function index were detected and compared between the two groups.Results: Before treatment, there was no significant difference in hs-CRP, sCD40L and TNF-alpha levels in the two groups. After treatment, the hs-CRP of the two groups were (5.01±1.95) mg/L, (9.41±2.48) mg/L, sCD40L were (1.88±0.25) ng/mL, (2.77±0.27) ng/mL, TNF-α were (8.86±2.18) ng/L, (15.52±2.78) ng/L, respectively. The levels of hs-CRP, sCD40L and TNF-α in the two groups were all decreased, and the level of each index in the observation group was lower than that of the control group. There was no significant difference in NO, ET-1 and vWF levels between the two groups before treatment. After treatment, the NO of the two groups were (82.48±11.57) umol/L and (66.68±13.18) umol/L, respectively. The two groups of NO were all elevated, and the NO of the observation group was higher than that of the control group. After treatment, the ET-1 of the two groups were (55.03±6.58) ng/L, (66.17±5.42) ng/L, and vWF were (66.17±5.88)×10-2, (83.28±5.39)×10-2, respectively. The ET-1 and vWF of the two groups were all decreased, and the ET-1 and vWF of the observation group were lower than those of the control group. There was no significant difference in LVEF, LVESD and LVEDD between the two groups before treatment. After treatment, the LVEF, LVESD and LVEDD of the observation group were (63.87±6.43)%, (38.27±4.66) mm and (43.63±7.61) mm, respectively. The LVEF of the observation group was higher than that of the control group, and the LVESD and LVEDD were lower than that of the control group.Conclusion: Tirofiban can effectively improve the inflammatory factors, endothelial function and cardiac function of AMI patients after interventional therapy.展开更多
基金Hubei Natural Science Foundation Project(2013CKB005).
文摘Objective:To investigate the effect of tironon on inflammatory factors, endothelial function and cardiac function after interventional therapy in AMI patients.Methods:A total of 120 patients with acute myocardial infarction in our hospital were selected as the research objects, all of them were in line with the indications of PCI operation. They were randomly divided into the observation group (60 cases) and the control group (60 cases). The control group was treated with aspirin and clopidogrel before and after PCI, and the observation group was treated with based on the use of tirofiban. Inflammatory factors, endothelial function and cardiac function index were detected and compared between the two groups.Results: Before treatment, there was no significant difference in hs-CRP, sCD40L and TNF-alpha levels in the two groups. After treatment, the hs-CRP of the two groups were (5.01±1.95) mg/L, (9.41±2.48) mg/L, sCD40L were (1.88±0.25) ng/mL, (2.77±0.27) ng/mL, TNF-α were (8.86±2.18) ng/L, (15.52±2.78) ng/L, respectively. The levels of hs-CRP, sCD40L and TNF-α in the two groups were all decreased, and the level of each index in the observation group was lower than that of the control group. There was no significant difference in NO, ET-1 and vWF levels between the two groups before treatment. After treatment, the NO of the two groups were (82.48±11.57) umol/L and (66.68±13.18) umol/L, respectively. The two groups of NO were all elevated, and the NO of the observation group was higher than that of the control group. After treatment, the ET-1 of the two groups were (55.03±6.58) ng/L, (66.17±5.42) ng/L, and vWF were (66.17±5.88)×10-2, (83.28±5.39)×10-2, respectively. The ET-1 and vWF of the two groups were all decreased, and the ET-1 and vWF of the observation group were lower than those of the control group. There was no significant difference in LVEF, LVESD and LVEDD between the two groups before treatment. After treatment, the LVEF, LVESD and LVEDD of the observation group were (63.87±6.43)%, (38.27±4.66) mm and (43.63±7.61) mm, respectively. The LVEF of the observation group was higher than that of the control group, and the LVESD and LVEDD were lower than that of the control group.Conclusion: Tirofiban can effectively improve the inflammatory factors, endothelial function and cardiac function of AMI patients after interventional therapy.
