To the Editor:With the development of clinical research and the application of cord blood,the clinical value of umbilical cord blood(UCB)has drawn more and more attention.UCB has been increasingly applied to treatment...To the Editor:With the development of clinical research and the application of cord blood,the clinical value of umbilical cord blood(UCB)has drawn more and more attention.UCB has been increasingly applied to treatments of hematological diseases,autoimmune diseases,and malignant tumors in children and adults[1]and has achieved high overall survival.[1–3]UCB contains substantial amounts of various stem cells,including hematopoietic stem cells(HSC),mesenchymal stem cells,endothelial progenitor cells,and so on[4];among them,HSC are most widely used in study and clinical application.Transplantation,where UCB HSC are implanted into patients,requires ruining the immune system and hematopoietic system before the procedure.Another therapeutic method is UCB infusion,where UCB is regarded as a nutrient,to improve the outcome of peripheral blood HSC transplantation[5]or symptoms via paracrine pathway of UCB stem cells.[6]In addition to the application of allogeneic UCB,autologous UCB has also been used in clinical treatment research.Autologous UCB is not limited to treating hemopathy,but also used to treat non-genetic metabolic disease,immune disease,and nervous system injury.[6]展开更多
基金This work was supported by the Guangzhou Municipality Tianhe Nuoya Bioengineering Co.Ltd.
文摘To the Editor:With the development of clinical research and the application of cord blood,the clinical value of umbilical cord blood(UCB)has drawn more and more attention.UCB has been increasingly applied to treatments of hematological diseases,autoimmune diseases,and malignant tumors in children and adults[1]and has achieved high overall survival.[1–3]UCB contains substantial amounts of various stem cells,including hematopoietic stem cells(HSC),mesenchymal stem cells,endothelial progenitor cells,and so on[4];among them,HSC are most widely used in study and clinical application.Transplantation,where UCB HSC are implanted into patients,requires ruining the immune system and hematopoietic system before the procedure.Another therapeutic method is UCB infusion,where UCB is regarded as a nutrient,to improve the outcome of peripheral blood HSC transplantation[5]or symptoms via paracrine pathway of UCB stem cells.[6]In addition to the application of allogeneic UCB,autologous UCB has also been used in clinical treatment research.Autologous UCB is not limited to treating hemopathy,but also used to treat non-genetic metabolic disease,immune disease,and nervous system injury.[6]
