The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic t...The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7𝜇m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials.展开更多
Electrospun nanofibers have been considered as relatively ideal material system for the design and construction of surgical wound dressings in the past few decades.Although there are lots of other biopolymers employed...Electrospun nanofibers have been considered as relatively ideal material system for the design and construction of surgical wound dressings in the past few decades.Although there are lots of other biopolymers employed for electrospinning,chitosan is one of the most important biopolymers for the fabrication of electrospun nanofibers,due to its nontoxic,antibacterial,biocompatible as well as biodegradable properties.Electrospun chitosan nanofibers with random or aligned fiber structure can further be cross-linked by physical,chemical and ionic crosslinking methods.The as-crosslinked electrospun chitosan nanofibrous membranes possess enhanced wet stability,improved mechanical property and good biocompatibility,which are necessary for wound healing application.The present work reviews the recent studies on the design and development of electrospun chitosan nanofibers and their applications for wound healing,such as antibacterial materials,hemostatic dressings,angiogenesis and immune regulation.展开更多
基金the financial supports from the China Postdoctoral Fund(2019M662299)the project fund of innovation and entrepreneurship training program for college students in Shandong Province(S202011065125).
文摘The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7𝜇m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials.
基金the financial supports from the China Postdoctoral Fund(2019M662299).
文摘Electrospun nanofibers have been considered as relatively ideal material system for the design and construction of surgical wound dressings in the past few decades.Although there are lots of other biopolymers employed for electrospinning,chitosan is one of the most important biopolymers for the fabrication of electrospun nanofibers,due to its nontoxic,antibacterial,biocompatible as well as biodegradable properties.Electrospun chitosan nanofibers with random or aligned fiber structure can further be cross-linked by physical,chemical and ionic crosslinking methods.The as-crosslinked electrospun chitosan nanofibrous membranes possess enhanced wet stability,improved mechanical property and good biocompatibility,which are necessary for wound healing application.The present work reviews the recent studies on the design and development of electrospun chitosan nanofibers and their applications for wound healing,such as antibacterial materials,hemostatic dressings,angiogenesis and immune regulation.
