Uncovering the potential pathological mechanism of acute pancreatitis in patients with COVID-19 by bioinformatics methods

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.

A new catalyst for urea oxidation: NiCo2S4 nanowires modified 3D carbon sponge

Urea oxidation is a significant reaction for utilizing urea-rich wastewater or human urine as sustainable power sources which can ease the water eutrophication while generate electricity. A direct urea-hydrogen peroxide fuel cell is a new kind of fuel cell employing urea as fuel and hydrogen peroxide as oxidant which possesses a larger cell voltage. Herein, this work tries to promote the kinetics process of urea oxidation by preparing low-cost and high-efficient NiCo2S4 nanowires modified carbon sponge electrode. The carbon sponge used in this work with a similar three-dimensional multi-channel structure to Ni foam, is prepared by carbonizing recycled polyurethane sponge which is also a process of recycling waste. The performance of the prepared catalyst in an alkaline solution is investigated in a three-electrode system.With the introduction of Co element to the catalyst, a reduced initial urea oxidation potential and a high performance are obtained. Furthermore, a direct urea-hydrogen peroxide fuel cell is assembled using the NiCo2S4 nanowires modified carbon sponge anode. Results indicate that the prepared catalyst provides a chance to solve the current problems that hinder the development of urea electrooxidation(high initial urea oxidation potential, low performance, and high electrode costs).

Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

Lithiated Graphdiyne Quantum Dots for Stable Lithium Metal Anodes

Here,a facile strategy is proposed for the preparation of lithiated graphdiyne quantum dots(GDY-Li QDs)with conjugated sp-and sp2-hybridized carbons by the self-assembly technique ofπ–πstacking of lithiated hexaethynylbezene under mild conditions.The as-prepared GDY-Li QDs,containing stacked multialkynyl aromatic backbone and abundant lithium(Li),show an average diameter of about 2.6 nm and good dispersion in the solvents.These distinctive structures endow GDY-Li QDs with superior properties that cannot be matched by traditional QDs,such as strong ion adsorption,Li-ion self-concentration,high Li-ion conductivity,the nanoconfinement effect,and ion solvation regulation.Benefiting from these features,GDY-Li QDs can stabilize Limetal anodes to effectively suppress Li-dendrite growth and significantly improve its Li plating/stripping coulombic efficiency(99.3%in the carbonate electrolyte).The full cells with GDY-Li QDs protected Li-metal anodes,and LiNi_(0.8)Co_(0.1)Mn^(0.1)O_(2)cathodes delivered high capacity and excellent cycling stability at high rates,which demonstrates the great potential of GDY-Li QDs for application in fast-charging Li-metal batteries.

新型冠状病毒感染防控新阶段公立医院运营面临的难题及思考

新型冠状病毒感染疫情以来,中国根据病毒特点采取科学的疫情防控,经历了不同的疫情防控阶段.自疫情防控"新十条"出台后,新型冠状病毒感染人数激增,给公立医院的救治工作带来了巨大的挑战.在新型冠状病毒感染防控新阶段,公立医院在应对疫情冲击的过程中暴露出许多弊端,本文对此进行分析总结,并提出新形势下提升医院诊治和救助能力的建议:①提升基层医院救治水平,缓解中心医院诊治压力;②优化分级分类诊疗模式,提高医院运营效率;③构建急救及重症救治系统大平台,平衡人员和各类物资供给;④推进"防治结合"的医疗模式,保障人民群众安全健康.

Development and validation of a predictive nomogram for sarcopenia among older people in China

To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.

Uniformly grown PtCo-modified C03O4 nanosheets as a highly efficient catalyst for sodium borohydride electrooxidation

A facile hydrothermal synthetic method, followed by in situ reduction and galvanic replacement processes, is used to prepare PtCo-modified Co304 nanosheets （PtCo/C0304 NSs） supported on Ni foam. The prepared nanomaterial is used as an electrocatalyst for NaBH4 oxidation in alkaline solution. The morphology and phase composition of PtCo/C0304 NSs are characterized by scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, X-ray diffraction （XRD）, and X-ray photoelectron spectroscopy （XPS）. The catalytic performance of PtCo/Co3O4 NSs is investigated by cyclic voltammetry （CV） and chronoamperometry （CA） in a standard three-electrode system. Current densities of 70 and 850 mA·cm^-2 were obtained at -0.4 V for Co/Co3O4 and PtCo/Co3O4 NSs, respectively, in a solution containing 2 mol·L^-1 NaOH and 0.2 mol·L^-1 NaBH4. The use of a noble metal （Pt） greatly enhances the catalytic activity of the transition metal （Co） and Co3O4. Besides, both Co and Co3O4 exhibit good B-H bond breaking ability （in NaBH4）, which leads to better electrocatalytic activity and stability of PtCo/Co3O4 NSs in NaBH4 electrooxidation compared to pure Pt. The results demonstrate that the as-prepared PtCo/Co3O4 NSs can be a promising electrocatalyst for borohydride oxidation.

Isolated superior mesenteric artery rupture caused by abdominal trauma

The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other.SMA injuries are usually classified as major visceral artery injuries,and have an incidence of<1%.The clinical manifestations of patients with SMA injuries include intra-abdominal bleeding and peritoneal irritation.The compromised blood supply can lead to intestinal ischemia and perforation.These injuries are often not diagnosed in time and have significant mortality rates of 25%-68%due to the lack of specific features(Maithel et al.,2020).Not only that,but patients with less severe trauma or no visible damage on initial examination may still have clinically significant intra-abdominal injuries(Nishijima et al.,2012).Emergency departments often encounter multiple cases that require urgent diagnosis and treatment(Li et al.,2021;Zhang et al.,2021;Zhou et al.,2021),and therefore,it is imperative to diagnose and manage these rare injuries expeditiously.