Abnormal synaptic plasticity causes cognitive deficits.Hippocampal long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP f...Abnormal synaptic plasticity causes cognitive deficits.Hippocampal long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP facilitation.Chinese medicine Dengzhan Shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates cognition.Our previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.展开更多
The authors regret there was an unfortunate error in the reproduction of Fig.1I in the article.In the original figure,the fluorescence picture of the positive control drug-ifenprodil was misused.The authors have corre...The authors regret there was an unfortunate error in the reproduction of Fig.1I in the article.In the original figure,the fluorescence picture of the positive control drug-ifenprodil was misused.The authors have corrected Fig.1I and provided the original fluorescence pictures of all groups(seven groups,n=5 for each group)to the editorial office.Below,the corrected Fig.1I is shown below.The authors declare that this correction does not affect the description,interpretation,or the original conclusions of the article.展开更多
基金the National Natural Science Foundation of China(Grant No.:82204341)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Grant No.:2022-I2M-2-002)the National Key Research and Development Program of China(Grant No.:2019YFC1708901).
文摘Abnormal synaptic plasticity causes cognitive deficits.Hippocampal long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP facilitation.Chinese medicine Dengzhan Shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates cognition.Our previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.
文摘The authors regret there was an unfortunate error in the reproduction of Fig.1I in the article.In the original figure,the fluorescence picture of the positive control drug-ifenprodil was misused.The authors have corrected Fig.1I and provided the original fluorescence pictures of all groups(seven groups,n=5 for each group)to the editorial office.Below,the corrected Fig.1I is shown below.The authors declare that this correction does not affect the description,interpretation,or the original conclusions of the article.
