Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular complications.Virus-induced endothelial dama...Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular complications.Virus-induced endothelial damage,endothelial barrier dysfunction,thrombosis,and cytokine storm are implicated in heart and multi-organ failure.展开更多
Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome ap...Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA （lncRNA）, a heteroge- neous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA （miRNA） pathways, lncRNA has been shown to act as both a source and an inhi- bitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying com- plexes by directing them to specific loci.展开更多
基金This work was supported by the British Heart Foundation(BHF)project grant“Targeting the SARS-CoV-2 S-protein binding to the ACE2 receptor to preserve human cardiac pericytes function in COVID-19”(PG/20/10285)(to P.M.and E.A.)European Commission H2020 CORDIS project COVIRNA(project/id/101016072)(to C.E.and P.K.S.)BHF Chair award(CH/15/1/31199)(to C.E).In addition,it was supported by a grant from the National Institute for Health Research(NIHR)Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.E.A.is a postdoctoral researcher supported by the Heart Research UK translational project grant“Targeting pericytes for halting pulmonary hypertension in infants with congenital heart disease”(RG2697/21/23)(to P.M.and E.A.).I.B.is an investigator of the Wellcome Trust(106115/Z/14/Z).
文摘Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic has caused over 670 million cases and 6.7 million deaths worldwide,many of which are attributed to cardiovascular complications.Virus-induced endothelial damage,endothelial barrier dysfunction,thrombosis,and cytokine storm are implicated in heart and multi-organ failure.
基金provided by the British Heart Foundation,UK(Grant No.CH/15/1/31199)
文摘Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA （lncRNA）, a heteroge- neous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA （miRNA） pathways, lncRNA has been shown to act as both a source and an inhi- bitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying com- plexes by directing them to specific loci.
