We set out to study the role of psychiatric comorbidity in the evolution of m igraine to medication overuse headache (MOH)- by a comparative study of 41 migr aineurs (MIG) and 41 patients suffering from MOH deriving f...We set out to study the role of psychiatric comorbidity in the evolution of m igraine to medication overuse headache (MOH)- by a comparative study of 41 migr aineurs (MIG) and 41 patients suffering from MOH deriving from migraine. There w as an excess risk of suffering from mood disorders [odds ratio (OR)=4.5, 95% c onfidence interval (CI) 1.5, 13.5], anxiety (OR=5, 95% CI 1.2, 10.7) and disor ders associated with the use of psychoactive substances other than analgesics (O R=7.6, 95% CI 2.2, 26.0) in MOH compared with MIG. Retrospective study of the order of occurrence of disorders showed that in the MOH group, psychiatric disor ders occurred significantly more often before the transformation from migraine i nto MOH than after. There was no crossed- family transmission between MOH and p sychiatric disorders, except for substance- related disorders. MOH patients hav e a greater risk of suffering from anxiety and depression, and these disorders m ay be a risk factor for the evolution of migraine into MOH. Moreover, MOH patien ts have a greater risk of suffering from substance- related disorders than MIG sufferers. This could be due to the fact that MOH is part of the spectrum of add ictive disorders.展开更多
文摘We set out to study the role of psychiatric comorbidity in the evolution of m igraine to medication overuse headache (MOH)- by a comparative study of 41 migr aineurs (MIG) and 41 patients suffering from MOH deriving from migraine. There w as an excess risk of suffering from mood disorders [odds ratio (OR)=4.5, 95% c onfidence interval (CI) 1.5, 13.5], anxiety (OR=5, 95% CI 1.2, 10.7) and disor ders associated with the use of psychoactive substances other than analgesics (O R=7.6, 95% CI 2.2, 26.0) in MOH compared with MIG. Retrospective study of the order of occurrence of disorders showed that in the MOH group, psychiatric disor ders occurred significantly more often before the transformation from migraine i nto MOH than after. There was no crossed- family transmission between MOH and p sychiatric disorders, except for substance- related disorders. MOH patients hav e a greater risk of suffering from anxiety and depression, and these disorders m ay be a risk factor for the evolution of migraine into MOH. Moreover, MOH patien ts have a greater risk of suffering from substance- related disorders than MIG sufferers. This could be due to the fact that MOH is part of the spectrum of add ictive disorders.
