期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
New Green Synthesis and Antineoplastic Activity of Bis (3-Arylimidazolidinyl-1) Methanes
1
作者 María Cristina Caterina Isabel A. Perillo +4 位作者 Ximena Villalonga Nicolás Amiano cristian payés Mercedes L. sanchez Alejandra salerno 《Open Journal of Medicinal Chemistry》 2013年第4期121-127,共7页
A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described. The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as sou... A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described. The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as sources of formaldehyde and the reactions were performed in heterogeneous phase catalyzed by an acidic ion-exchange resin (Amberlyst 15). The compounds were tested with the Sulforhodamine B assay according to the protocol of the National Cancer Institute for several cell lines. The results were expressed as percentage inhibition of growth cell in comparison with the full growth of the cells without treatment. Cytotoxicity on normal cells using the Annexing-PI staining and flow cytometry has been evaluated. The parent compound, bis(3-phenylimidazolidinyl-1)methane 1 and the monohalogenated derivatives 4-chlorophenyl 3 and 3-bromophenyl 5 showed antineoplastic activity, 60%, 82% and 89% inhibition growth cell respectively on the human colon cell line (HCT116). The 4-tolyl derivative 6 presented inhibitory activity (73% inhibition of growth cell) on human lung adenocarcinoma cell line (A549) and 62% on human mammary cell line MCF-7. 展开更多
关键词 BIS (3-Arylimidazolidinyl-1) Methanes Amberlyst-15 ANTICANCER Activity Cancer Cell LINES Sulforhodamine B
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部