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Using old liver grafts for liver transplantation: Where are the limits? 被引量:11
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作者 Carlos Jiménez-Romero Oscar Caso Maestro +6 位作者 Félix Cambra Molero Iago Justo Alonso cristina alegre torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González 《World Journal of Gastroenterology》 SCIE CAS 2014年第31期10691-10702,共12页
The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts ... The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors &#x0003e; 60 years, donors with hypernatremia or macrosteatosis &#x0003e; 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time &#x0003e; 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. 展开更多
关键词 Old liver donors Liver transplantation Aging liver Liver graft Liver disease AGING Donor management Septuagenarian donors Octogenarian donors
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