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Temperature and eluent composition effects on enantiomer separation of carvedilol by high-performance liquid chromatography on immobilized amylose-based chiral stationary phases 被引量:1
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作者 cristina panella Rosella Ferretti +1 位作者 Adriano Casulli Roberto Cirilli 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2019年第5期324-331,共8页
Carvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. He... Carvedilol is a chiral drug with potent antihypertensive and antianginal activities. Although it is clinically used as a racemic mixture, its enantiomers show different pharmacokinetic and pharmacodynamic profiles. Here, the direct chiral separation of racemic drug by high performance liquid chromatography using two immobilized-type amylose-based chiral stationary phases is presented. Some chromatographic parameters, such as retention and selectivity, were determined under multimodal eluent conditions and different temperatures. A temperature-dependent inversion of the elution order of enantiomers was observed in the operative temperature range of chiral chromatographic support. Finally, an effective direct enantioselective method was successfully applied to the separation of the enantiomers of carvedilol on a semipreparative scale. 展开更多
关键词 Chiralpak^(■) IG-3 Enantioselective HPLC CARVEDILOL Column temperature Isoenantioselective temperature Semipreparative enantioseparation
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