Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,mo...Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,most strongly in the liver,muscles,and many other tissues[2,3].Studies with mice[4,5]and human patients[6]have shown the beneficial effects of short-term fasting during anti-cancer chemotherapy treatments.展开更多
Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast...Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fasting exhibits a sexual dimorphism in the immune system[5].展开更多
基金the Spanish association against cancer(AECC)(id:SIRTBIO-LABAE18008FERN and PRDMA18011PAST)Pablo J.Fernandez-Marcos has been funded by a Ramon y Cajal Award from the Spanish Ministry of Science,Innovation and Universities(MICINN)(RYC-2017-22335)+2 种基金Marta Barradas and Cristina Pantoja have been funded by Madrid Institute for Advanced Studies(IMDEA)Food.Jose L.López-Aceituno has been funded by the Spanish Ministry of Science and Innovation(MICINN)(PTA2017-14689-I)Work at the laboratory of Pablo J.Fernandez-Marcos was funded by the AECC(SIRTBIO-LABAE18008FERN)the RETOS projects Programme of MICINN(SAF2017-85766-R and PID2020-114077RB-I00).
文摘Dear Editor,Short-term fasting(up to 48 hours)activates strong physiological and molecular responses[1].We and others showed a p53-independent transcriptional activation of the cell cycle inhibitor p21 upon fasting,most strongly in the liver,muscles,and many other tissues[2,3].Studies with mice[4,5]and human patients[6]have shown the beneficial effects of short-term fasting during anti-cancer chemotherapy treatments.
基金Andrés Pastor Fernández was a recipient of a predoc-toral fellowship from the Spanish Association Against Cancer-AECC(PRDMA18011PAST)Cristina Pantoja and Marta Barradas were funded by the Madrid Institute for Advanced Studies(IMDEA)Food.Adrián Plaza was funded by the AECC(SIRTBIO-LABAE18008FERN)+7 种基金Jose Luis Lopez-Aceituno was funded by the Spanish Ministry of Science and Innovation(MICINN)(PTA2017-14689-I).Pablo Jose Fernandez-Marcos was funded by a Ramon y Cajal Award from the Spanish Ministry of Science,Innovation and Universities(MICINN)(RYC-2017-22335/AEI/10.13039/501100011033)Work at the laboratory of Pablo Jose Fernández-Marcos was funded by the AECC(SIRTBIO-LABAE18008FERN)and the RETOS Program projects from the MICINN(SAF2017-85766-R/AEI/10.13039/501100011033 and PID2020-114077RB-I00/AEI/10.13039/501100011033)Work in Lola Martínez flow cytometry unit was funded by the CNIO.Manuel Montero Gómez de las Heras and Jose Ignacio Escrig-Larena were supported by FPU grants(FPU19/02576 and FPU20/04066,respectively)from the Spanish Ministry of ScienceInnovation and Universities.Work in the laboratory of Maria Mittelbrunn was supported by the Fondo de Investigación Sanitaria del Instituto de Salud CarlosⅢ(PI19/855)the European Regional Development Fund(ERDF)and the European Commission through H2020-EU.1.1,European Research Council grant ERC-2016-StG 715322-EndoMitTalk,and the Y2020/BIO-6350 NutriSION-CM synergy grant from Comunidad de MadridEsther Durán was funded by the Centro de Estudios Universitarios(CEU)San Pablo University.Alejo Efeyan is an EMBO Young Investiga-tor.Alejo Efeyan lab is supported by the Retos Projects Program of the Spanish Ministry of Science,Innovation and Universities,the Spanish State Research Agency(AEI/10.13039/501100011033)co-funded by the European Regional Development Fund(PID 2019-104012RB-I00)a FERO Grant for Research in Oncology,and La Caixa Foundation(HR21-00046).
文摘Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fasting exhibits a sexual dimorphism in the immune system[5].
