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Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at different ages
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作者 Daniel Perez-Torres cruz reyes-vázquez +1 位作者 Mireya Velázquez-Paniagua Bertha P rieto-Gómez 《Advances in Aging Research》 2014年第1期29-34,共6页
Melatonin, the pineal indole is characterized by being a compound that crosses all cell membranes and which has been attributed to several mechanisms of action. Among these it is the ability to reduce free radicals, t... Melatonin, the pineal indole is characterized by being a compound that crosses all cell membranes and which has been attributed to several mechanisms of action. Among these it is the ability to reduce free radicals, thereby reducing the potential aging and cell death. Studies in different age Wistar rats have shown that chronic application of melatonin, in the hippocampus, reduces the concentration of free radicals and keeps its architecture. This study showed that melatonin increases the firing rate and favors the presence of bursting activity in animals of different ages. It is suggested that melatonin conserved hippocampal cells in good anatomical and physiological condition probably as a result of the elimination of free radicals. 展开更多
关键词 MELATONIN UNITARY NEURONAL Activity HIPPOCAMPUS RAT Age
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Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model
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作者 Bertha Prieto Gómez cruz reyes-vázquez Mireya Velázquez-Paniagua 《Advances in Aging Research》 2014年第4期318-325,共8页
Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and c... Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a “best” state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells. 展开更多
关键词 RAT MELATONIN HIPPOCAMPUS ANTIOXIDANT AGING
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