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生物节律紊乱与肿瘤发生的原由探秘 被引量:5
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作者 彭飞 崔柏 +3 位作者 苏柯予 张晓雨 王岑心 刘强 《中国科学:生命科学》 CSCD 北大核心 2021年第12期1721-1733,共13页
生物节律是维持生物体各项生理功能内稳态的重要保障,调控重要的日常生物过程和行为.近年来,由于外界环境变化和不良生活方式引起的机体生物节律紊乱已成为导致多种疾病的重要原因,其中节律紊乱与肿瘤发生发展具有密切关联.研究表明,生... 生物节律是维持生物体各项生理功能内稳态的重要保障,调控重要的日常生物过程和行为.近年来,由于外界环境变化和不良生活方式引起的机体生物节律紊乱已成为导致多种疾病的重要原因,其中节律紊乱与肿瘤发生发展具有密切关联.研究表明,生物节律紊乱通过打破机体的基因表达、代谢方式、免疫应答、神经内分泌和肠道菌群等方面的生理平衡而促进肿瘤的恶性进展,其中节律反馈机制的失调是打破生物节律"阴阳"平衡引起肿瘤恶化的普遍规律.因此,通过行为干预恢复生物体节律、抗肿瘤药物时间疗法的运用和靶向生物钟基因药物的开发已成为利用时间生物学治疗癌症的重要方向.综上,本文将系统性地总结节律紊乱与肿瘤调控之间的关系,并为时间生物学在肿瘤领域的应用提供新的研究视角和治疗策略. 展开更多
关键词 生物钟 肿瘤 节律紊乱 生活方式 癌症治疗
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Influence of influent on anaerobic ammonium oxidation in an Expanded Granular Sludge Bed-Biological Aerated Filter integrated system 被引量:2
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作者 Daijun ZHANG cui bai +1 位作者 Ting TANG Qing YANG 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2011年第2期291-297,共7页
Shortcut nitrification-denitrification,anaerobic ammonium oxidation(ANAMMOX),and methanogenesis have been successfully coupled in an Expanded Granular Sludge Bed-Biological Aerated Filter(EGSB-BAF)integrated system.As... Shortcut nitrification-denitrification,anaerobic ammonium oxidation(ANAMMOX),and methanogenesis have been successfully coupled in an Expanded Granular Sludge Bed-Biological Aerated Filter(EGSB-BAF)integrated system.As fed different synthetic wastewater with chemical oxygen demand(COD)of 300-1200 mg·L^(-1)and NH_(4)^(+)-N of 30-120 mg·L^(-1)at the outer recycle ratio of 200%,the influence of influent on ANAMMOX in the integrated system was investigated in this paper.The experimental results showed that higher COD concentration caused an increase in denitrification and methanogenesis but a decrease in ANAMMOX;however,when an influent with the low concentration of COD was used,the opposite changes could be observed.Higher influent NH_(4)^(+)-N concentration favored ANAMMOX when the COD concentration of influent was fixed.Therefore,low COD=NH_(4)^(+)-N ratio would decrease competition for nitrite between ANAMMOX and denitrification,which was favorable for reducing the negative effect of organic COD on ANAMMOX.The good performance of the integrated system indicated that the bacterial community of denitrification,ANAMMOX,and methanogenesis could be dynamically maintained in the sludge of EGSB reactor for a certain range of influent. 展开更多
关键词 Expanded Granular Sludge Bed-Biological Aerated Filter(EGSB-BAF)integrated system the influence of influent anaerobic ammonium oxidation(ANAMMOX) shortcut nitrification-denitrification METHANOGENESIS
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