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铁基纳米粒子制备及用于pH响应双模态磁共振成像引导下肿瘤光热治疗 被引量:5
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作者 刘建华 王雷 +6 位作者 张天琪 王建秋 龚雪 崔凤至 郑建军 李波 施展 《分析化学》 SCIE EI CAS CSCD 北大核心 2019年第5期678-685,共8页
肿瘤早期诊断对于选择合适的治疗方案至关重要,而单一模态磁共振成像(MRI)难以满足精确诊断的要求。本研究构建了聚丙烯酸(PAA)修饰的Fe_3O_4@MnO_2纳米粒子(Fe_3O_4@MnO_2@PAA)用于pH响应的T_1/T_2双模态MR成像,同时能够介导肿瘤的光... 肿瘤早期诊断对于选择合适的治疗方案至关重要,而单一模态磁共振成像(MRI)难以满足精确诊断的要求。本研究构建了聚丙烯酸(PAA)修饰的Fe_3O_4@MnO_2纳米粒子(Fe_3O_4@MnO_2@PAA)用于pH响应的T_1/T_2双模态MR成像,同时能够介导肿瘤的光热治疗。以Fe_3O_4为核,可以使Fe_3O_4@MnO_2@PAA纳米粒子在磁共振成像的T_2信号明显减低; MnO_2纳米壳在肿瘤内的酸性环境下可分解为顺磁性的Mn^(2+),能够增强T_1信号。这种pH响应的T_1/T_2双模态MRI造影剂具有良好的敏感性和特异性,可以为肿瘤诊断提供更全面、更详实的信息。此外,Fe_3O_4@MnO_2@PAA纳米粒子在近红外区表现出优异的吸收能力,可作为一种良好的光热转换材料介导肿瘤的光热治疗。这种pH响应的双模态磁共振成像介导光热治疗的新型纳米诊疗剂,在肿瘤的MRI诊断及光热治疗方面表现出良好的应用潜能。 展开更多
关键词 诊疗剂 磁共振成像 双模态成像 近红外光 光热治疗
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Earthquake detection probabilities and completeness magnitude in the northern margin of the Ordos Block
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作者 Zhang Fan Yang Xiao-Zhong cui feng-zhi 《Applied Geophysics》 SCIE 2024年第4期777-793,881,共18页
The assessment of the completeness of earthquake catalogs is a prerequisite for studying the patterns of seismic activity.In traditional approaches,the minimum magnitude of completeness(MC)is employed to evaluate cata... The assessment of the completeness of earthquake catalogs is a prerequisite for studying the patterns of seismic activity.In traditional approaches,the minimum magnitude of completeness(MC)is employed to evaluate catalog completeness,with events below MC being discarded,leading to the underutilization of the data.Detection probability is a more detailed measure of the catalog's completeness than MC;its use results in better model compatibility with data in seismic activity modeling and allows for more comprehensive utilization of seismic observation data across temporal,spatial,and magnitude dimensions.Using the magnitude-rank method and Maximum Curvature(MAXC)methods,we analyzed temporal variations in earthquake catalog completeness,fi nding that MC stabilized after 2010,which closely coincides with improvements in monitoring capabilities and the densifi cation of seismic networks.Employing the probability-based magnitude of completeness(PMC)and entire magnitude range(EMR)methods,grounded in distinct foundational assumptions and computational principles,we analyzed the 2010-2023 earthquake catalog for the northern margin of the Ordos Block,aiming to assess the detection probability of earthquakes and the completeness of the earthquake catalog.The PMC method yielded the detection probability distribution for 76 stations in the distance-magnitude space.A scoring metric was designed based on station detection capabilities for small earthquakes in the near fi eld.From the detection probabilities of stations,we inferred detection probabilities of the network for diff erent magnitude ranges and mapped the spatial distribution of the probability-based completeness magnitude.In the EMR method,we employed a segmented model fi tted to the observed data to determine the detection probability and completeness magnitude for every grid point in the study region.We discussed the sample dependency and low-magnitude failure phenomena of the PMC method,noting the potential overestimation of detection probabilities for lower magnitudes and the underestimation of MC in areas with weaker monitoring capabilities.The results obtained via the two methods support these hypotheses.The assessment results indicate better monitoring capabilities on the eastern side of the study area but worse on the northwest side.The spatial distribution of network monitoring capabilities is uneven,correlating with the distribution of stations and showing signifi cant diff erences in detection capabilities among diff erent stations.The truncation eff ects of data and station selection aff ected the evaluation results at the edges of the study area.Overall,both methods yielded detailed descriptions of the earthquake catalog,but careful selection of calculation parameters or adjustments based on the strengths of diff erent methods is necessary to correct potential biases. 展开更多
关键词 magnitude of completeness northern margin of the Ordos Block PMC method EMR method earthquake detection probability
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