Kaposi's sarcoma (KS) is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus (HIV)-positive patients.According to the clinical characteri...Kaposi's sarcoma (KS) is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus (HIV)-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively:classic,endemic to Africa,acquired immunodeficiency syndrome (AIDS)-associated,and immunosuppression associated type.Bullous pemphigoid (BP) is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G (IgG) deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 (HHV-8) in the pathogenic mechanism.展开更多
文摘Kaposi's sarcoma (KS) is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus (HIV)-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively:classic,endemic to Africa,acquired immunodeficiency syndrome (AIDS)-associated,and immunosuppression associated type.Bullous pemphigoid (BP) is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G (IgG) deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 (HHV-8) in the pathogenic mechanism.