Background Both ischemic preconditioning (IPC) and limb remote ischemic postconditioning (LRIPOC) have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfu...Background Both ischemic preconditioning (IPC) and limb remote ischemic postconditioning (LRIPOC) have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfusion injury (IRI), but no study has compared the anti-inflammatory effects of IPC and LRIPOC during myocardial IRI process. We hypothesized that IPC and LRIPOC would produce different anti-inflammatory effects in an in vivo rat model with myocardial IRI.展开更多
To the editor: In a retrospective observational clinical study including 482 elderly patients with coronary heart diseaseundergoing elective major noncardiac surgery, Liu et al' showed that the incidence ofperiopera...To the editor: In a retrospective observational clinical study including 482 elderly patients with coronary heart diseaseundergoing elective major noncardiac surgery, Liu et al' showed that the incidence ofperioperative major adverse cardiac events (MACEs) was 12.7%, and five risk factors were independently associated with perioperative MACEs. This study makes an important contribution to the effort to define risk factors for perioperative MACEs in elderly patients with coronary heart disease undergoing noncardiac surgery. Strengths of this study include a large sample of patients and most of the known risk factors that can affect perioperative MACEs. Furthermore, the authors have used appropriate methods to identify independent risk factors for perioperative MACEs. However, in our view, there are several aspects of this study that should be considered.展开更多
文摘Background Both ischemic preconditioning (IPC) and limb remote ischemic postconditioning (LRIPOC) have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfusion injury (IRI), but no study has compared the anti-inflammatory effects of IPC and LRIPOC during myocardial IRI process. We hypothesized that IPC and LRIPOC would produce different anti-inflammatory effects in an in vivo rat model with myocardial IRI.
文摘To the editor: In a retrospective observational clinical study including 482 elderly patients with coronary heart diseaseundergoing elective major noncardiac surgery, Liu et al' showed that the incidence ofperioperative major adverse cardiac events (MACEs) was 12.7%, and five risk factors were independently associated with perioperative MACEs. This study makes an important contribution to the effort to define risk factors for perioperative MACEs in elderly patients with coronary heart disease undergoing noncardiac surgery. Strengths of this study include a large sample of patients and most of the known risk factors that can affect perioperative MACEs. Furthermore, the authors have used appropriate methods to identify independent risk factors for perioperative MACEs. However, in our view, there are several aspects of this study that should be considered.