Manipulation of gene expression through targeting specific DNA or RNA sequences is a significant challenge, tn the past decade, transcription activator-like （TAL） effectors and zinc fingers （ZFs） have been success...Manipulation of gene expression through targeting specific DNA or RNA sequences is a significant challenge, tn the past decade, transcription activator-like （TAL） effectors and zinc fingers （ZFs） have been successfully developed into useful tools for DNA recognition （Bogdanove and Voytas, 2011; Deng et al., 2012a, 2012b）. However, little progress has been made in the realm of RNA targeting due to the lack of understanding about the modular RNA recognition mechanism.展开更多
基金This work was funded by the National Natural Science Foundation of China （Program No. 31200567）, the Fundamental Research Funds for the Central Universities （Program No. 2014JQ001）, and the Huazhong Agricultural University Scientific ＆ Technological Self-innovation Foundation （Program No. 2013RC013）.ACKNOWLEDGMENTS No conflict of interest declared.
文摘Manipulation of gene expression through targeting specific DNA or RNA sequences is a significant challenge, tn the past decade, transcription activator-like （TAL） effectors and zinc fingers （ZFs） have been successfully developed into useful tools for DNA recognition （Bogdanove and Voytas, 2011; Deng et al., 2012a, 2012b）. However, little progress has been made in the realm of RNA targeting due to the lack of understanding about the modular RNA recognition mechanism.
