期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Protective Effects of Blocking Renin-Angiotensin System on the Progression of Renal Injury in Glomerulosclerosis 被引量:11
1
作者 ZequanJi cuiwenhuang +3 位作者 ChengjieLiang BoChen ShengqiangChen WeiwenSun 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2005年第2期150-154,共5页
To investigate the protective effects of blocking rennin-angiotensin system(RAS)on the progression of renal injury in glomerulosclerosis,a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and be... To investigate the protective effects of blocking rennin-angiotensin system(RAS)on the progression of renal injury in glomerulosclerosis,a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and being injected with Adriamycin into caudal vein.The rats with glomerulosclerosis were randomly divided as ten per group into those without further treatment(group D)and those treated with Benazepril(group DB),Losartan (group DL),or sham-operation(group C),respectively.After 6 weeks of administration of Benazepril or Losartan, the mRNA expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in renal cortex were measured by RT-PCR.Besides, the expressions of TGF-β_1,ET-1 and iNOS at protein level were detected by Western blotting and the concentrations of Col Ⅳ and Fn were analyzed with immunohistochemistry respectively.Results showed that the rats in group D appeared as obvious proteinuria,hypoalbuminemia and hypercholesterolemia,which had a significant difference compared with group C(p<0.05),and most of their mesangiums were detected with cellular proliferation and significant increasing for extracellular matrix.Renal cortex TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in rats of group D were increased by 3.59,2.57,2.21,2.58 and 3.28 times at mRNA level,and by 2.60,1.40,0.75,1.83 and 2.15 times at protein level,respectively,compared with group C.When the animals were treated with Benazepril(group DB)or Losartan(group DL),however,the biochemical and pathological damages were significantly recovered,and protein expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS were also significantly diminished(p<0.05).This study suggested that blocking RAS using Benazepril or Losartan can have protective effects on the renal injury in glomerulosclerosis by down-regulating the expressions of TGF-β_1, Col Ⅳ,Fn,ET-1 and iNOS.Cellular & Molecular Immunology.2005;2(2):150-154. 展开更多
关键词 GLOMERULOSCLEROSIS rennin-angiotensin system BENAZEPRIL LOSARTAN
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部