Meyoid derived suppressor cells(MDSCs)are heterogeneous myeloid cell populations that expand in pathological conditions such as cancer,autoimmunity,and infection;these cells are also known to exert strong immunosuppre...Meyoid derived suppressor cells(MDSCs)are heterogeneous myeloid cell populations that expand in pathological conditions such as cancer,autoimmunity,and infection;these cells are also known to exert strong immunosuppressive effects on primitive Tcell responses.1 MDSCs are derived from myeloid progenitors and are arrested at an immature phase of differentiation.In mice,normal bone marrow contains~20–30%cells exhibiting the MDSC phenotype.2 In contrast,a very low number of MDSCs are found in naive spleens(2–4%),and these cells are completely absent in lymph nodes.展开更多
基金supported by the Natural Science Foundation of Jiangsu Province of China(Grant number BK20180825)supported by the National Natural Science Foundation of China(31872732).
文摘Meyoid derived suppressor cells(MDSCs)are heterogeneous myeloid cell populations that expand in pathological conditions such as cancer,autoimmunity,and infection;these cells are also known to exert strong immunosuppressive effects on primitive Tcell responses.1 MDSCs are derived from myeloid progenitors and are arrested at an immature phase of differentiation.In mice,normal bone marrow contains~20–30%cells exhibiting the MDSC phenotype.2 In contrast,a very low number of MDSCs are found in naive spleens(2–4%),and these cells are completely absent in lymph nodes.
