The production and usage amount of pesticides in US rank the leading position in the world. On the basis of protecting the environment and human health, US government has enacted a series of laws and regulations to no...The production and usage amount of pesticides in US rank the leading position in the world. On the basis of protecting the environment and human health, US government has enacted a series of laws and regulations to normalize and manage the production and use of pesticides so as to ensure the development of modern agriculture. In this paper, US pesticide management system is briefly reviewed and compared with the pesticide management system of China, which may provide good reference for china in establishing its own management system and make steps towards the international standard.展开更多
Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction(DGBI),in which the intestinal microbiota plays an important role.Microglia are the“sentinels...Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction(DGBI),in which the intestinal microbiota plays an important role.Microglia are the“sentinels”of the central nervous system(CNS),which participate in tissue damage caused by traumatic brain injury,resist central infection and participate in neurogenesis,and are involved in the occurrence of various neurological diseases.With in-depth research on DGBI,we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI,especially in individuals with comorbidities of mental disorders,such as irritable bowel syndrome(IBS).This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI.In this review,we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI,especially IBS,and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities.展开更多
文摘The production and usage amount of pesticides in US rank the leading position in the world. On the basis of protecting the environment and human health, US government has enacted a series of laws and regulations to normalize and manage the production and use of pesticides so as to ensure the development of modern agriculture. In this paper, US pesticide management system is briefly reviewed and compared with the pesticide management system of China, which may provide good reference for china in establishing its own management system and make steps towards the international standard.
基金This work was supported by the National Key R&D Program of China(No.2021YFA1301300,2019YFA0905600)the National Natural Science Foundation of China(No.82170557,81670491,82000510).
文摘Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction(DGBI),in which the intestinal microbiota plays an important role.Microglia are the“sentinels”of the central nervous system(CNS),which participate in tissue damage caused by traumatic brain injury,resist central infection and participate in neurogenesis,and are involved in the occurrence of various neurological diseases.With in-depth research on DGBI,we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI,especially in individuals with comorbidities of mental disorders,such as irritable bowel syndrome(IBS).This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI.In this review,we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI,especially IBS,and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities.
