Background: Renal and ocular vessels are some of the major vessels affected in patients with diabetes, and the involvement of these vessels is independent risk factors for other complications. Hemodynamic flow in arte...Background: Renal and ocular vessels are some of the major vessels affected in patients with diabetes, and the involvement of these vessels is independent risk factors for other complications. Hemodynamic flow in arteries may be assessed by using measures such as resistive index, which is a non-invasive measure of the resistance in vessels. The association between retinopathy and nephropathy has been conflicting. This study assessed the relationship between resistive index of the central retinal artery and indices of nephropathy in type 2 diabetes. Method: This cross-sectional study examined 74 Nigerian diabetics who were selected consecutively from the out-patient diabetic clinic of a tertiary hospital in South-West Nigeria. Doppler ultrasound was used to determine the resistive index of the central retinal artery along with the right renal artery. The urinary and serum biochemical parameters were also done to determine the urinary albumin excretion and the glomerular filtration rate. Results: The mean age of participants was 59.62 ± 9.55 years. The mean central retinal artery resistive index (CRARI) was 0.77 ± 0.06, with 65 (87.8%) of the participants having elevated CRARI. There was no statistical difference between patients with normal CRARI and elevated CRARI in respect of their urinary albumin excretion (p = 0.796). There was no significant correlation between CRARI and estimated glomerular filtration rate (r = 0.120;p = 0.309) and right renal artery resistive index (r = 0.068;p = 0.564). Conclusion: This study demonstrates that central retinal artery resistive index (CRARI) may not be a predictor of renal function in diabetics.展开更多
Background: Presence of metabolic syndrome (MS) in people with diabetes confers increased cardiovascular and diabetes-specific micro- and macrovascular complications. The pathogenic pathways for metabolic syndrome are...Background: Presence of metabolic syndrome (MS) in people with diabetes confers increased cardiovascular and diabetes-specific micro- and macrovascular complications. The pathogenic pathways for metabolic syndrome are still issues for discussion especially in some special groups like those with type 2 diabetes mellitus (T2DM). Recent evidences suggest that inflammation may play a key role in MS. This study assessed the relationship between MS (and its component risks) and markers of inflammation (high-sensitivity C-reactive protein {hs-CRP} and white blood cells {WBC}). Methods: A cross-sectional study involving 108 patients with T2DM. Anthropometric measurements and clinical examination were conducted. Blood sample was collected for hs-CRP, WBC, glycated haemoglobin etc. Metabolic syndrome was defined using the International Diabetes Federation criteria. Ethical approval was granted and informed consent was obtained from participants. Results: Mean age of male and female participants were 58.00 ± 7.01 years and 55.48 ± 8.35 years respectively (p = 0.092). Eighty-two (75.9%) participants had metabolic syndrome. Median values of hs-CRP and total WBC were 0.89mg/L and 5.73 x103/mm3 respectively. On correlation, hs-CRP showed statistically significant association with waist circumference (r = 0.194;p = 0.044), fasting plasma glucose (r = 0.191;p = 0.048) and serum triglycerides (p = 0.226;r = 0.019). There was no statistically significant association between WBC and the metabolic components. Conclusion: Prevalence of metabolic syndrome is high, and C-reactive protein was associated with waist circumference, fasting plasma glucose and serum triglycerides.展开更多
文摘Background: Renal and ocular vessels are some of the major vessels affected in patients with diabetes, and the involvement of these vessels is independent risk factors for other complications. Hemodynamic flow in arteries may be assessed by using measures such as resistive index, which is a non-invasive measure of the resistance in vessels. The association between retinopathy and nephropathy has been conflicting. This study assessed the relationship between resistive index of the central retinal artery and indices of nephropathy in type 2 diabetes. Method: This cross-sectional study examined 74 Nigerian diabetics who were selected consecutively from the out-patient diabetic clinic of a tertiary hospital in South-West Nigeria. Doppler ultrasound was used to determine the resistive index of the central retinal artery along with the right renal artery. The urinary and serum biochemical parameters were also done to determine the urinary albumin excretion and the glomerular filtration rate. Results: The mean age of participants was 59.62 ± 9.55 years. The mean central retinal artery resistive index (CRARI) was 0.77 ± 0.06, with 65 (87.8%) of the participants having elevated CRARI. There was no statistical difference between patients with normal CRARI and elevated CRARI in respect of their urinary albumin excretion (p = 0.796). There was no significant correlation between CRARI and estimated glomerular filtration rate (r = 0.120;p = 0.309) and right renal artery resistive index (r = 0.068;p = 0.564). Conclusion: This study demonstrates that central retinal artery resistive index (CRARI) may not be a predictor of renal function in diabetics.
文摘Background: Presence of metabolic syndrome (MS) in people with diabetes confers increased cardiovascular and diabetes-specific micro- and macrovascular complications. The pathogenic pathways for metabolic syndrome are still issues for discussion especially in some special groups like those with type 2 diabetes mellitus (T2DM). Recent evidences suggest that inflammation may play a key role in MS. This study assessed the relationship between MS (and its component risks) and markers of inflammation (high-sensitivity C-reactive protein {hs-CRP} and white blood cells {WBC}). Methods: A cross-sectional study involving 108 patients with T2DM. Anthropometric measurements and clinical examination were conducted. Blood sample was collected for hs-CRP, WBC, glycated haemoglobin etc. Metabolic syndrome was defined using the International Diabetes Federation criteria. Ethical approval was granted and informed consent was obtained from participants. Results: Mean age of male and female participants were 58.00 ± 7.01 years and 55.48 ± 8.35 years respectively (p = 0.092). Eighty-two (75.9%) participants had metabolic syndrome. Median values of hs-CRP and total WBC were 0.89mg/L and 5.73 x103/mm3 respectively. On correlation, hs-CRP showed statistically significant association with waist circumference (r = 0.194;p = 0.044), fasting plasma glucose (r = 0.191;p = 0.048) and serum triglycerides (p = 0.226;r = 0.019). There was no statistically significant association between WBC and the metabolic components. Conclusion: Prevalence of metabolic syndrome is high, and C-reactive protein was associated with waist circumference, fasting plasma glucose and serum triglycerides.
