studies indicated that restenosis rate was higher after multiple stents implantation than single stent. Restenosis following stent is mainly due to neointimal hyperplasia and takes place frequently at sites between th...studies indicated that restenosis rate was higher after multiple stents implantation than single stent. Restenosis following stent is mainly due to neointimal hyperplasia and takes place frequently at sites between the stents (In between) and at the central articulation (CA) of Palmaz Schatz stents. To understand this process, we compared serial [post intervention and follow up (FU, 6±2 months)] intravascular ultrasound studies in 86 stents implanted into 30 native and 11 saphenous vein graft lesions. Each lesion had more than one stent (16?mm long) placed closely to each other. Lumen and stent areas (mm 2) were measured; plaque (stent lumen) area, late lumen loss (D lumen area) and tissure growth (D plaque area) were calculated for the edges, bodys, In between, and CA of all stents. The lumen at sites between the stents and at the central articulation are smaller than at the bodys or edges of the stents because of slightly smaller stent area and superimposed prolapse of tissue through the sites between thestents and through the central articulation. Subsequent accumulation of neoimtimal tissue is uniformly throughout the stent. [BHDFG1*2,WK7,WK5,WK4。2,WK5,WK5W]EdgeBodyCAIn betweenANOVA P [BHDZG1*2,WK7ZQ,WK5,WK4。2,WK5,WK5ZQ*3/5W]Post stent area10.3±2.59.4±2.39.2±3.09.1±3.1<0.0?001[BHDWG1*2,WK7ZQ,WK5,WK4。2,WK5,WK5W]FU stent area9.7±3.19.3±3.19.0±3.58.9±3.70.001[BH,WK7ZQ,WK5,WK4。2,WK5,WK5W]Post lumen area10.1±2.69.3±3.29.0±3.98.6±4.1<0.0?001FU lumen area6.9±3.76.4±3.55.9±4.15.4±3.8<0.0?001Post plaque area0.0±0.20.0±0.00.5±1.10.7±1.4<0.0?001FU palque area2.9±2.13.1±1.93.2±2.43.4±2.50.002Late lumen loss3.2±2.12.9±2.03.1±2.83.3±2.6NSTissue growth2.7±2.52.8±2.32.8±2.52.9±2.6NS Serial intravascular ultrasound imaging shows that restenosis at the locations between the stents (compared to the edges or body) of Palmaz Schatz is the result of smaller initial lumen and tissue prolapse (similar as at CA) and not due to an increased neointimal tissue accumulation. Thus, long stent design may reduce stent restenosis.展开更多
文摘studies indicated that restenosis rate was higher after multiple stents implantation than single stent. Restenosis following stent is mainly due to neointimal hyperplasia and takes place frequently at sites between the stents (In between) and at the central articulation (CA) of Palmaz Schatz stents. To understand this process, we compared serial [post intervention and follow up (FU, 6±2 months)] intravascular ultrasound studies in 86 stents implanted into 30 native and 11 saphenous vein graft lesions. Each lesion had more than one stent (16?mm long) placed closely to each other. Lumen and stent areas (mm 2) were measured; plaque (stent lumen) area, late lumen loss (D lumen area) and tissure growth (D plaque area) were calculated for the edges, bodys, In between, and CA of all stents. The lumen at sites between the stents and at the central articulation are smaller than at the bodys or edges of the stents because of slightly smaller stent area and superimposed prolapse of tissue through the sites between thestents and through the central articulation. Subsequent accumulation of neoimtimal tissue is uniformly throughout the stent. [BHDFG1*2,WK7,WK5,WK4。2,WK5,WK5W]EdgeBodyCAIn betweenANOVA P [BHDZG1*2,WK7ZQ,WK5,WK4。2,WK5,WK5ZQ*3/5W]Post stent area10.3±2.59.4±2.39.2±3.09.1±3.1<0.0?001[BHDWG1*2,WK7ZQ,WK5,WK4。2,WK5,WK5W]FU stent area9.7±3.19.3±3.19.0±3.58.9±3.70.001[BH,WK7ZQ,WK5,WK4。2,WK5,WK5W]Post lumen area10.1±2.69.3±3.29.0±3.98.6±4.1<0.0?001FU lumen area6.9±3.76.4±3.55.9±4.15.4±3.8<0.0?001Post plaque area0.0±0.20.0±0.00.5±1.10.7±1.4<0.0?001FU palque area2.9±2.13.1±1.93.2±2.43.4±2.50.002Late lumen loss3.2±2.12.9±2.03.1±2.83.3±2.6NSTissue growth2.7±2.52.8±2.32.8±2.52.9±2.6NS Serial intravascular ultrasound imaging shows that restenosis at the locations between the stents (compared to the edges or body) of Palmaz Schatz is the result of smaller initial lumen and tissue prolapse (similar as at CA) and not due to an increased neointimal tissue accumulation. Thus, long stent design may reduce stent restenosis.
