五味双柏散外敷缓解疼痛在髋关节置换术后快速康复中的临床应用

【目的】探讨五味双柏散外敷缓解疼痛在髋关节置换术(THA)后早期快速康复中的临床应用效果。【方法】选择行单侧THA患者64例,随机分为试验组33例和对照组31例。2组患者均于术后当天、第1天、第2天常规给予静脉注射帕瑞昔布钠40 mg,每日2次,后均改为口服塞来昔布胶囊200 mg,每日2次。试验组在此基础上,术后第1天给予伤口下缘外敷五味双柏散,每日2次。所有患者若仍有疼痛则额外给予盐酸曲马多缓释片口服。记录2组患者住院天数、住院期间所用曲马多剂量,以及术后第2天、第4天患者的疼痛视觉模拟评分(VAS)情况。【结果】(1)试验组患者的住院天数少于对照组,盐酸曲马多缓释片用量少于对照组,差异有统计学意义(P<0.01)。(2)术后第2天,2组患者VAS评分比较,差异无统计学意义(P>0.05);术后第4天,2组患者VAS评分均较术后第2天改善(P<0.05或P<0.01),且试验组对VAS评分的改善作用明显优于对照组,差异有统计学意义(P<0.01)。【结论】五味双柏散外敷可以减轻THA术后患者的疼痛不适,减少镇痛药物的应用,缩短住院周期,促进THA术后患者的快速康复。

Granulocyte-macrophage colony-stimulating factor and interleukin 4 induce the malignant transformation of the bone marrow- derived human adult mesenchymal stem cells

Background The purpose of the study was to examine the effects of granulocyte-macrophage colony-stimulating factor （GM-CSF） and interleukin 4 （IL-4） on the bone-marrow-derived human adult mesenchymal stem cells （hMSCs）. Methods The hMSCs were isolated and cultured with GM-CSF and IL-4 for a period of one month. A single colony of transformed cells was then isoloated and their phenotype was characterized by morphology, surface marker expression, and in vivo tumorigenesis.Results After one month culture, the transformed mesenchymal cells exhibited the morphology and phenotype similar to those of tumor cells, and also caused multiple fast growing lung deposits when it was injected into immunodeficient mice.Conclusion Cytokines-driven malignant transformation of hMSCs may be a useful model for studying signaling pathways initiating malignant transformation of hMSC.