目的:通过对早泄患者脑白质网络节点与边的介数中心性(BC)拓扑属性值的探讨,分析关键脑区及脑区间白质结构连接重要性与患者射精功能的相关性。方法:收集18例早泄患者和22例年龄、学历匹配的正常对照者的一般人口学及临床资料,并采集其...目的:通过对早泄患者脑白质网络节点与边的介数中心性(BC)拓扑属性值的探讨,分析关键脑区及脑区间白质结构连接重要性与患者射精功能的相关性。方法:收集18例早泄患者和22例年龄、学历匹配的正常对照者的一般人口学及临床资料,并采集其大脑T1相结构数据与弥散张量成像(DTI)扫描数据;预处理所有被试T1与DTI数据,使用解剖学自动标记模板(AAL)将大脑分割为90个左右对称的皮质与皮质下区域(定义为脑网络节点),并通过概率性脑白质纤维追踪技术计算不同脑区之间的结构连接(定义为脑网络节点之间的边),同时基于脑连接工具箱(BCT)计算被试脑白质网络节点与边的介数中心性拓扑属性值,最后对节点与边介数中心性属性值进行组间Mann-Whitney U检验,并对统计结果进行错误发现率(FDR)校正,同时对组间差异属性值和患者射精功能进行Pearson相关性分析。结果:①患者组脑白质网络右侧枕上回介数中心性属性值较对照组显著下降(67.78±58.98 vs 281.18±255.26,Z=-3.49,校正后P<0.05)。②患者组脑白质网络右侧颞上回介数中心性属性值较对照组显著上升(557.00±322.65 vs 222.91±155.60,Z=3.55,校正后P<0.05)。③患者右侧罗兰多壳盖与右侧脑岛之间白质结构连接介数中心性属性值较对照组显著上升(23.83±23.91 vs 4.23±8.39,Z=3.84,校正后P<0.05)。④患者组右侧枕上回介数中心性属性值与其性生活时延迟射精的困难程度评分呈负相关(r=-0.51,P=0.03),与其射精发生在想射精之前几率呈负相关(r=-0.61,P=0.01);患者组右侧颞上回介数中心性属性值与其射精太早困扰程度评分呈正相关(r=0.54,P=0.02),与其担心射精时间可能让配偶不满程度评分(r=0.47,P=0.04)呈正相关。结论:早泄患者右侧大脑半球与视觉、情绪相关的皮质出现结构连接的紊乱,其可能参与患者射精过快或射精控制力下降症状的发生,同时可能导致患者出现一系列心理问题。展开更多
Background Her-2/neu gene overexpression has been found in several malignancies, and is associated with poor prognosis; while its role in the tumorigenesis and progression of prostate cancer （PCa） is still controver...Background Her-2/neu gene overexpression has been found in several malignancies, and is associated with poor prognosis; while its role in the tumorigenesis and progression of prostate cancer （PCa） is still controversial. This study aimed to evaluate the prognostic value of Her-2/neu protein expression and clinicopathologic factors in antiandrogen-treated Chinese men with PCa for disease progression and PCa-specific death. Methods Her-2/neu protein expression was determined using immunohistochemistry （IHC） in specimens collected from 124 prostate biopsies and transurethral resection of prostate （TURP） from seven prostate cancer patients. Results Her-2/neu protein expression was 0, 1＋, 2＋, and 3＋ in 40 （30.5%）, 8 （6.1%）, 67 （51.1%）, and 16 （12.2%） cases respectively. Her-2/neu protein expression showed significant correlation as judged by Gleason score （P=0.049）, clinical tumor-node-metastases （cTNM） stage （P=0.018） and disease progression （P=0.001）, but did not correlate with prostate-specific antigen （PSA） （P=0.126） or PCa-specific death （P=0.585）. PSA （P=0.001）, Gleason score （P=0.017）, cTNM （P=-0.000） and Her-2/neu protein expression （P=0.001） had prognostic value for evaluating the progression of PCa in univariate analysis. In Kaplan-Meier plots, both Gleason score （P=0.035） and cTNM （P=0.013） correlated with PCa-specific death. In multivariate analysis, only cTNM was significant for both disease progression （P=0.001） and PCa-specific death （P=0.031）. Conclusions Her-2/neu protein expression is significantly correlated with Gleason score, cTNM and disease progression, although it is not an independent predictor of disease progression and PCa-specific death, cTNM staging serves as an independent prognostic factor for disease progression and PCa-specific death.展开更多
文摘目的:通过对早泄患者脑白质网络节点与边的介数中心性(BC)拓扑属性值的探讨,分析关键脑区及脑区间白质结构连接重要性与患者射精功能的相关性。方法:收集18例早泄患者和22例年龄、学历匹配的正常对照者的一般人口学及临床资料,并采集其大脑T1相结构数据与弥散张量成像(DTI)扫描数据;预处理所有被试T1与DTI数据,使用解剖学自动标记模板(AAL)将大脑分割为90个左右对称的皮质与皮质下区域(定义为脑网络节点),并通过概率性脑白质纤维追踪技术计算不同脑区之间的结构连接(定义为脑网络节点之间的边),同时基于脑连接工具箱(BCT)计算被试脑白质网络节点与边的介数中心性拓扑属性值,最后对节点与边介数中心性属性值进行组间Mann-Whitney U检验,并对统计结果进行错误发现率(FDR)校正,同时对组间差异属性值和患者射精功能进行Pearson相关性分析。结果:①患者组脑白质网络右侧枕上回介数中心性属性值较对照组显著下降(67.78±58.98 vs 281.18±255.26,Z=-3.49,校正后P<0.05)。②患者组脑白质网络右侧颞上回介数中心性属性值较对照组显著上升(557.00±322.65 vs 222.91±155.60,Z=3.55,校正后P<0.05)。③患者右侧罗兰多壳盖与右侧脑岛之间白质结构连接介数中心性属性值较对照组显著上升(23.83±23.91 vs 4.23±8.39,Z=3.84,校正后P<0.05)。④患者组右侧枕上回介数中心性属性值与其性生活时延迟射精的困难程度评分呈负相关(r=-0.51,P=0.03),与其射精发生在想射精之前几率呈负相关(r=-0.61,P=0.01);患者组右侧颞上回介数中心性属性值与其射精太早困扰程度评分呈正相关(r=0.54,P=0.02),与其担心射精时间可能让配偶不满程度评分(r=0.47,P=0.04)呈正相关。结论:早泄患者右侧大脑半球与视觉、情绪相关的皮质出现结构连接的紊乱,其可能参与患者射精过快或射精控制力下降症状的发生,同时可能导致患者出现一系列心理问题。
文摘Background Her-2/neu gene overexpression has been found in several malignancies, and is associated with poor prognosis; while its role in the tumorigenesis and progression of prostate cancer （PCa） is still controversial. This study aimed to evaluate the prognostic value of Her-2/neu protein expression and clinicopathologic factors in antiandrogen-treated Chinese men with PCa for disease progression and PCa-specific death. Methods Her-2/neu protein expression was determined using immunohistochemistry （IHC） in specimens collected from 124 prostate biopsies and transurethral resection of prostate （TURP） from seven prostate cancer patients. Results Her-2/neu protein expression was 0, 1＋, 2＋, and 3＋ in 40 （30.5%）, 8 （6.1%）, 67 （51.1%）, and 16 （12.2%） cases respectively. Her-2/neu protein expression showed significant correlation as judged by Gleason score （P=0.049）, clinical tumor-node-metastases （cTNM） stage （P=0.018） and disease progression （P=0.001）, but did not correlate with prostate-specific antigen （PSA） （P=0.126） or PCa-specific death （P=0.585）. PSA （P=0.001）, Gleason score （P=0.017）, cTNM （P=-0.000） and Her-2/neu protein expression （P=0.001） had prognostic value for evaluating the progression of PCa in univariate analysis. In Kaplan-Meier plots, both Gleason score （P=0.035） and cTNM （P=0.013） correlated with PCa-specific death. In multivariate analysis, only cTNM was significant for both disease progression （P=0.001） and PCa-specific death （P=0.031）. Conclusions Her-2/neu protein expression is significantly correlated with Gleason score, cTNM and disease progression, although it is not an independent predictor of disease progression and PCa-specific death, cTNM staging serves as an independent prognostic factor for disease progression and PCa-specific death.
