目的:探讨使用数字化技术设计和制作个性化定制导板治疗颞下颌关节强直患者的临床意义。方法:基于患者CT数据,联合运用软件Mimics 19.0(Materialise,Belgium)及Geomagic studio 2014(Geomagic Inc,America)设计及制作个性化导板,并用3D...目的:探讨使用数字化技术设计和制作个性化定制导板治疗颞下颌关节强直患者的临床意义。方法:基于患者CT数据,联合运用软件Mimics 19.0(Materialise,Belgium)及Geomagic studio 2014(Geomagic Inc,America)设计及制作个性化导板,并用3D打印机输出导板,用于手术中定位截骨。结果:将数字化导板技术用于颞下颌关节强直手术,引导术中截骨,缩短手术时间,提高手术精确度,同时也保护了重要组织结构。结论:数字化导板技术为治疗颞下颌关节强直患者提供了一种有效途径。展开更多
Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxo...Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.展开更多
文摘目的:探讨使用数字化技术设计和制作个性化定制导板治疗颞下颌关节强直患者的临床意义。方法:基于患者CT数据,联合运用软件Mimics 19.0(Materialise,Belgium)及Geomagic studio 2014(Geomagic Inc,America)设计及制作个性化导板,并用3D打印机输出导板,用于手术中定位截骨。结果:将数字化导板技术用于颞下颌关节强直手术,引导术中截骨,缩短手术时间,提高手术精确度,同时也保护了重要组织结构。结论:数字化导板技术为治疗颞下颌关节强直患者提供了一种有效途径。
基金supported by the Natural Science Foundation of China(U1802281,31770388)
文摘Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.
