Spinal cord injury （SCI） is a devastating medical condition without a cure. Reestablishment of neuronal connections after spinal cord injury is the ＂holy grail＂ of SCI research. However, grafting exogenous cells, ...Spinal cord injury （SCI） is a devastating medical condition without a cure. Reestablishment of neuronal connections after spinal cord injury is the ＂holy grail＂ of SCI research. However, grafting exogenous cells, including neural stem cells and a variety of adult somatic cells, has had very lim- ited success [1]. Two back-to-back papers published in the Proceedings of National Academy of Sciences USA by the Li and Sun groups have provided exciting information by bringing activated endogenous neurogenesis into play, using a biomaterial called chitosan that was loaded with neu- rotrophic factor 3 （NT3） to achieve slow release of the trophic factor. Moreover, these papers have provided a mechanistic insight using analyses of gene expression and neuronal function.展开更多
脊髓损伤是尚未解决的重大医学难题.在脊髓损伤研究中,损伤后重建神经元联系被奉为研究圣杯.人们为此进行了外源细胞移植（包括神经干细胞以及各种成年体细胞）的实验研究,却鲜有成功[1].最近,李晓光和孙毅团队在Proceedings of the Nat...脊髓损伤是尚未解决的重大医学难题.在脊髓损伤研究中,损伤后重建神经元联系被奉为研究圣杯.人们为此进行了外源细胞移植（包括神经干细胞以及各种成年体细胞）的实验研究,却鲜有成功[1].最近,李晓光和孙毅团队在Proceedings of the National Academy of Sciences of the United States of America上连续发表2篇文章,成果令人兴奋.展开更多
文摘Spinal cord injury （SCI） is a devastating medical condition without a cure. Reestablishment of neuronal connections after spinal cord injury is the ＂holy grail＂ of SCI research. However, grafting exogenous cells, including neural stem cells and a variety of adult somatic cells, has had very lim- ited success [1]. Two back-to-back papers published in the Proceedings of National Academy of Sciences USA by the Li and Sun groups have provided exciting information by bringing activated endogenous neurogenesis into play, using a biomaterial called chitosan that was loaded with neu- rotrophic factor 3 （NT3） to achieve slow release of the trophic factor. Moreover, these papers have provided a mechanistic insight using analyses of gene expression and neuronal function.
文摘脊髓损伤是尚未解决的重大医学难题.在脊髓损伤研究中,损伤后重建神经元联系被奉为研究圣杯.人们为此进行了外源细胞移植（包括神经干细胞以及各种成年体细胞）的实验研究,却鲜有成功[1].最近,李晓光和孙毅团队在Proceedings of the National Academy of Sciences of the United States of America上连续发表2篇文章,成果令人兴奋.
