Due to inappropriate planning and management, accelerated urban growth and tremendous loss in land, especially cropland, have become a great challenge for sustainable urban development in China, especially in develope...Due to inappropriate planning and management, accelerated urban growth and tremendous loss in land, especially cropland, have become a great challenge for sustainable urban development in China, especially in developed urban area in the coastal regions; therefore, there is an urgent need to effectively detect and monitor the land use changes and provide accurate and timely information for planning and management. In this study a method combining principal component analysis (PCA) of multisensor satellite images from SPOT (systeme pour l'observation de la terre or earth observation satellite)-5 multispectral (XS) and Landsat-7 enhanced thematic mapper (ETM) panchromatic (PAN) data, and supervised classification was used to detect and analyze the dynamics of land use changes in the city proper of Hangzhou. The overall accuracy of the land use change detection was 90.67% and Kappa index was 0.89. The results indicated that there was a considerable land use change (10.03% of the total area) in the study area from 2001 to 2003, with three major types of land use conversions: from cropland into built-up land, construction site, and water area (fish pond). Changes from orchard land into built-up land were also detected. The method described in this study is feasible and useful for detecting rapid land use change in the urban area.展开更多
Background Pelizaeus-Merzbacher disease （PMD） is a rare X-linked recessive disorder with symptoms including nystagmus, impaired motor development, ataxia, and progressive spasticity. The proteolipidprotein 1 （PLP1...Background Pelizaeus-Merzbacher disease （PMD） is a rare X-linked recessive disorder with symptoms including nystagmus, impaired motor development, ataxia, and progressive spasticity. The proteolipidprotein 1 （PLP1） gene is the only pathogenic gene of PMD. Duplication of the PLP1 gene is the most frequent gene defect, accounting for 50%-70% of PMD cases, whereas point mutations in the coding sequence or the splice sites account for 10%-25% of PMD cases. This study aimed to identify PLP1 mutations in nine unrelated Chinese patients （P1-9） with PMD, and 14 subjects from the family of patient 2 were also described. Methods Genomic DNA was extracted from peripheral multiplex ligation-dependent probe amplification （MLPA）. AI amplified and analyzed using direct DNA sequencing. blood samples. Gene dosage was determined using the 7 exons and exon-intron boundaries of the PLP1 gene were Results Of these nine patients, there were four transitional, four classical, and one connatal PMD according to their clinical and radiological presentations. PLP1 duplications were identified in patients 1-7 with PMD. Their mothers were PLPI duplications carriers as well. Both duplication carriers and normal genotypes of PLP1 were identified in the family members of patient 2. A c.517C〉T （p. P173S） hemizygous missense mutation in exon 4 was found in patient 8 with PMD, and his mother was shown to be a heterozygote of this mutation. Conclusions We identified seven genomic duplications and one missense mutation （p. P173S） of the PLP1 gene in eight Chinese patients with PMD. This is the report about PLP1 mutations in PMD patients from the mainland of China.展开更多
Al-BTC MOFs were prepared in a facile manner via a solvothermal reaction and characterized using FT-IR, XRD, and SEM. The compound was then evaluated as an adsorbent to remove Congo red(CR) from an aqueous solution. T...Al-BTC MOFs were prepared in a facile manner via a solvothermal reaction and characterized using FT-IR, XRD, and SEM. The compound was then evaluated as an adsorbent to remove Congo red(CR) from an aqueous solution. The adsorption kinetics was evaluated using the pseudo-first-order and pseudo-second-order, and it was found that the adsorption of CR onto the MOFs was well described by the pseudo-second-order equation. The as-prepared MOFs adsorbent seems to be a promising material in practice for dyes removal from aqueous solution.展开更多
基金supported by the National Natural Science Foundation of China (NSFC) (No.30571112).
文摘Due to inappropriate planning and management, accelerated urban growth and tremendous loss in land, especially cropland, have become a great challenge for sustainable urban development in China, especially in developed urban area in the coastal regions; therefore, there is an urgent need to effectively detect and monitor the land use changes and provide accurate and timely information for planning and management. In this study a method combining principal component analysis (PCA) of multisensor satellite images from SPOT (systeme pour l'observation de la terre or earth observation satellite)-5 multispectral (XS) and Landsat-7 enhanced thematic mapper (ETM) panchromatic (PAN) data, and supervised classification was used to detect and analyze the dynamics of land use changes in the city proper of Hangzhou. The overall accuracy of the land use change detection was 90.67% and Kappa index was 0.89. The results indicated that there was a considerable land use change (10.03% of the total area) in the study area from 2001 to 2003, with three major types of land use conversions: from cropland into built-up land, construction site, and water area (fish pond). Changes from orchard land into built-up land were also detected. The method described in this study is feasible and useful for detecting rapid land use change in the urban area.
文摘Background Pelizaeus-Merzbacher disease （PMD） is a rare X-linked recessive disorder with symptoms including nystagmus, impaired motor development, ataxia, and progressive spasticity. The proteolipidprotein 1 （PLP1） gene is the only pathogenic gene of PMD. Duplication of the PLP1 gene is the most frequent gene defect, accounting for 50%-70% of PMD cases, whereas point mutations in the coding sequence or the splice sites account for 10%-25% of PMD cases. This study aimed to identify PLP1 mutations in nine unrelated Chinese patients （P1-9） with PMD, and 14 subjects from the family of patient 2 were also described. Methods Genomic DNA was extracted from peripheral multiplex ligation-dependent probe amplification （MLPA）. AI amplified and analyzed using direct DNA sequencing. blood samples. Gene dosage was determined using the 7 exons and exon-intron boundaries of the PLP1 gene were Results Of these nine patients, there were four transitional, four classical, and one connatal PMD according to their clinical and radiological presentations. PLP1 duplications were identified in patients 1-7 with PMD. Their mothers were PLPI duplications carriers as well. Both duplication carriers and normal genotypes of PLP1 were identified in the family members of patient 2. A c.517C〉T （p. P173S） hemizygous missense mutation in exon 4 was found in patient 8 with PMD, and his mother was shown to be a heterozygote of this mutation. Conclusions We identified seven genomic duplications and one missense mutation （p. P173S） of the PLP1 gene in eight Chinese patients with PMD. This is the report about PLP1 mutations in PMD patients from the mainland of China.
基金supported by the Natural Science Foundation of Fujian Province (No. 2017J01420 and 2018H0030)Education Bureau of Fujian Province (JZ160453)Fujian Provincial Key Laboratory of Featured Materials in Biochemical Industry (FJKL_FBCM201902)。
文摘Al-BTC MOFs were prepared in a facile manner via a solvothermal reaction and characterized using FT-IR, XRD, and SEM. The compound was then evaluated as an adsorbent to remove Congo red(CR) from an aqueous solution. The adsorption kinetics was evaluated using the pseudo-first-order and pseudo-second-order, and it was found that the adsorption of CR onto the MOFs was well described by the pseudo-second-order equation. The as-prepared MOFs adsorbent seems to be a promising material in practice for dyes removal from aqueous solution.
