Protein glycosylation,one of the most common post-translational modifications,is implicated in the occurrence and development of many diseases.The biological functions of glycopeptides are realized by the collaborativ...Protein glycosylation,one of the most common post-translational modifications,is implicated in the occurrence and development of many diseases.The biological functions of glycopeptides are realized by the collaborative effects of both the sugar structure and peptide sequence.However,due to the complexity and diversity of glycopeptides,it is difficult to obtain a wide range of structurally well-defined glycopeptides for biofunctional studies and development of glycopeptide-based drugs.展开更多
Gprotein-coupled receptors(GPCRs)play a crucial role in cell signal transduction and comprise the largest drug target protein family.Despite recent breakthroughs in structural and pharmacological studies of these rece...Gprotein-coupled receptors(GPCRs)play a crucial role in cell signal transduction and comprise the largest drug target protein family.Despite recent breakthroughs in structural and pharmacological studies of these receptors,over 100 GPCRs remain orphan receptors,i.e.,their ligands and signaling pathways are unknown.This limits the full understanding of the physiological functions and signaling mechanisms of the GPCR superfamily.As a“virgin land”of drug discovery,orphan receptors thus offer new opportunities for drug development by serving as potential drug targets.展开更多
文摘Protein glycosylation,one of the most common post-translational modifications,is implicated in the occurrence and development of many diseases.The biological functions of glycopeptides are realized by the collaborative effects of both the sugar structure and peptide sequence.However,due to the complexity and diversity of glycopeptides,it is difficult to obtain a wide range of structurally well-defined glycopeptides for biofunctional studies and development of glycopeptide-based drugs.
文摘Gprotein-coupled receptors(GPCRs)play a crucial role in cell signal transduction and comprise the largest drug target protein family.Despite recent breakthroughs in structural and pharmacological studies of these receptors,over 100 GPCRs remain orphan receptors,i.e.,their ligands and signaling pathways are unknown.This limits the full understanding of the physiological functions and signaling mechanisms of the GPCR superfamily.As a“virgin land”of drug discovery,orphan receptors thus offer new opportunities for drug development by serving as potential drug targets.
