Periodontitis is a chronic infectious disease characterized by plaque biofilm as its main pathogenic factor;its clinical manifestations include gingival inflammation,alveolar bone resorption,attachment loss,and period...Periodontitis is a chronic infectious disease characterized by plaque biofilm as its main pathogenic factor;its clinical manifestations include gingival inflammation,alveolar bone resorption,attachment loss,and periodontal pocket formation,all of which eventually lead to tooth loss and seriously affect the quality of life of patients[1].This illness has a close relationship with blood sugar levels in patients with diabetes and is one of the most important complications of diabetes[2].Macrophages are an important part of host immune responses and exhibit powerful functions of identifying,phagocytizing,and removing bacteria;macrophage polarization is involved in the pathogenesis of periodontitis[3].展开更多
Periodontitis is a chronic inflammatory disease resulting in the loss of periodontal tissues and ultimately teeth,thus posing a substantial public-health burden worldwide[1].With the widespread increase in mesenchymal...Periodontitis is a chronic inflammatory disease resulting in the loss of periodontal tissues and ultimately teeth,thus posing a substantial public-health burden worldwide[1].With the widespread increase in mesenchymal stem cell(MSC)therapy and the discovery of MSCs in periodontal ligaments[2],periodontal ligament stem cells(PDLSCs)have been used to reconstruct periodontal tissue and repair bone defects[2,3].Furthermore.展开更多
基金supported by grants from the National Natural Science Foundation of China [No.81570945 to DING Gang]the Natural Science Foundation of Shandong Province [No.ZR2021MH051 to DING Gang+2 种基金No.ZR2020MH188 to LIU Yun Xia]2021 Youth Innovation Talent Introduction and Education Program of Shandong Province Universities (The innovative team for molecular epidemiology of oral cancer based on multiomics)Postgraduate Education Quality Improvement Plan of Shandong Province [No.SDYAL21150 to DING Gang]
文摘Periodontitis is a chronic infectious disease characterized by plaque biofilm as its main pathogenic factor;its clinical manifestations include gingival inflammation,alveolar bone resorption,attachment loss,and periodontal pocket formation,all of which eventually lead to tooth loss and seriously affect the quality of life of patients[1].This illness has a close relationship with blood sugar levels in patients with diabetes and is one of the most important complications of diabetes[2].Macrophages are an important part of host immune responses and exhibit powerful functions of identifying,phagocytizing,and removing bacteria;macrophage polarization is involved in the pathogenesis of periodontitis[3].
基金supported by grants from the Natural Science Foundation of Shandong Province[No.ZR2021MH051 to DING Gang]the Postgraduate Education Quality Improvement Plan of Shandong Province[No.SDYAL21150 to DING Gang]the National Natural Science Foundation of China[No.81570945 to DING Gang]
文摘Periodontitis is a chronic inflammatory disease resulting in the loss of periodontal tissues and ultimately teeth,thus posing a substantial public-health burden worldwide[1].With the widespread increase in mesenchymal stem cell(MSC)therapy and the discovery of MSCs in periodontal ligaments[2],periodontal ligament stem cells(PDLSCs)have been used to reconstruct periodontal tissue and repair bone defects[2,3].Furthermore.
