中医基于整体观念及辨证论治思想治疗胃癌前病变(precancerous lesions of gastric cancer,PLGC)具有一定优势。目前临床一般分为肝胃气滞证、肝胃郁热证、脾胃虚弱证(含脾胃虚寒证)、脾胃湿热证、胃阴不足证、胃络瘀血证6种证型论治,...中医基于整体观念及辨证论治思想治疗胃癌前病变(precancerous lesions of gastric cancer,PLGC)具有一定优势。目前临床一般分为肝胃气滞证、肝胃郁热证、脾胃虚弱证(含脾胃虚寒证)、脾胃湿热证、胃阴不足证、胃络瘀血证6种证型论治,对不同证型PLGC患者确立相应治法,运用中药方剂治疗,可改善患者胃黏膜病理状态、胃镜表现和临床症状,达到逆转癌前病变状态的目的,降低胃癌发病率。今后还需完善PLGC中医诊疗共识意见,重点对疗效明显的中药复方或单体开展研究,并增加临床研究随访次数,评估远期疗效。展开更多
目的:分析先天性二尖瓣-主动脉瓣间纤维假性动脉瘤(pseudoaneurysm of the mitral aortic intervalvular fibrosa,PMAIVF)的彩色多普勒超声心动图特征,评价超声对PMAIVF的诊断价值。方法:回顾性分析2008年6月至2020年1月在上海交通大学...目的:分析先天性二尖瓣-主动脉瓣间纤维假性动脉瘤(pseudoaneurysm of the mitral aortic intervalvular fibrosa,PMAIVF)的彩色多普勒超声心动图特征,评价超声对PMAIVF的诊断价值。方法:回顾性分析2008年6月至2020年1月在上海交通大学医学院附属上海儿童医学中心及苏州大学附属儿童医院经CTA、MRI及外科手术证实的4例PMAIVF的超声心动图检查资料。结果:PMAIVF声像图特征为二尖瓣与主动脉瓣间的囊袋样膨出,与左心室流出道交通,收缩期血流进入瘤内,瘤体膨起;舒张期血流返回入左心室,瘤体塌陷。4例患儿中,超声诊断符合3例,误诊为左心房内二尖瓣前瓣根部占位1例。结论:多普勒超声心动图技术可以比较准确地诊断PMAIVF,但容易误诊,需要与主动脉瓣周脓肿、心房内占位、冠状动脉瘘等相鉴别。展开更多
This study investigated hypolipidemic,weight-reducing,and hepatoprotective effects of Antrodia cinnamomea mycelial extract obtained from solid-state culture(ACME)in an HFr D-induced obese/hyperlipidemic mouse model.Fo...This study investigated hypolipidemic,weight-reducing,and hepatoprotective effects of Antrodia cinnamomea mycelial extract obtained from solid-state culture(ACME)in an HFr D-induced obese/hyperlipidemic mouse model.Following 4-week ACME treatment,body weight,epididymal fat index,and some serum biochemical indices were measured.Expression levels of some related genes involved in cholesterol and lipid metabolism were analyzed by q RT-PCR.Moreover,histological studies of hepatic tissues were also conducted.After ACME treatment,body weight and epididymal fat index were significantly lower than that in model control group.ACME and simvastatin significantly reduced serum total cholesterol(T-CHO)and low-density lipoprotein cholesterol(LDL-C)levels,and increased high-density lipoprotein cholesterol(HDL-C)level.Subsequent experiments showed that:(i)ACME regulated transcriptional expression of 3-hydroxy-3-methylglutaryl-Co A reductase(HMGR),low-density lipoprotein receptor(LDLR),adipose triglyceride lipase(ATGL),and fatty acid synthase(FAS),with consequent reduction of blood lipid levels and body weight;(ii)ACME enhanced total antioxidant capacity(T-AOC)and superoxide dismutase(SOD)activity in hepatic tissues;(iii)ACME reduced malondialdehyde(MDA)level and ameliorated lipid oxidative damage in liver.Our findings indicate that ACME is a strong candidate for development as a novel anti-hyperlipidemia and anti-obesity health product.展开更多
文摘中医基于整体观念及辨证论治思想治疗胃癌前病变(precancerous lesions of gastric cancer,PLGC)具有一定优势。目前临床一般分为肝胃气滞证、肝胃郁热证、脾胃虚弱证(含脾胃虚寒证)、脾胃湿热证、胃阴不足证、胃络瘀血证6种证型论治,对不同证型PLGC患者确立相应治法,运用中药方剂治疗,可改善患者胃黏膜病理状态、胃镜表现和临床症状,达到逆转癌前病变状态的目的,降低胃癌发病率。今后还需完善PLGC中医诊疗共识意见,重点对疗效明显的中药复方或单体开展研究,并增加临床研究随访次数,评估远期疗效。
文摘目的:分析先天性二尖瓣-主动脉瓣间纤维假性动脉瘤(pseudoaneurysm of the mitral aortic intervalvular fibrosa,PMAIVF)的彩色多普勒超声心动图特征,评价超声对PMAIVF的诊断价值。方法:回顾性分析2008年6月至2020年1月在上海交通大学医学院附属上海儿童医学中心及苏州大学附属儿童医院经CTA、MRI及外科手术证实的4例PMAIVF的超声心动图检查资料。结果:PMAIVF声像图特征为二尖瓣与主动脉瓣间的囊袋样膨出,与左心室流出道交通,收缩期血流进入瘤内,瘤体膨起;舒张期血流返回入左心室,瘤体塌陷。4例患儿中,超声诊断符合3例,误诊为左心房内二尖瓣前瓣根部占位1例。结论:多普勒超声心动图技术可以比较准确地诊断PMAIVF,但容易误诊,需要与主动脉瓣周脓肿、心房内占位、冠状动脉瘘等相鉴别。
基金Fundamental Research Funds for the Central Universities of China(2662019PY066,2662016PY132)。
文摘This study investigated hypolipidemic,weight-reducing,and hepatoprotective effects of Antrodia cinnamomea mycelial extract obtained from solid-state culture(ACME)in an HFr D-induced obese/hyperlipidemic mouse model.Following 4-week ACME treatment,body weight,epididymal fat index,and some serum biochemical indices were measured.Expression levels of some related genes involved in cholesterol and lipid metabolism were analyzed by q RT-PCR.Moreover,histological studies of hepatic tissues were also conducted.After ACME treatment,body weight and epididymal fat index were significantly lower than that in model control group.ACME and simvastatin significantly reduced serum total cholesterol(T-CHO)and low-density lipoprotein cholesterol(LDL-C)levels,and increased high-density lipoprotein cholesterol(HDL-C)level.Subsequent experiments showed that:(i)ACME regulated transcriptional expression of 3-hydroxy-3-methylglutaryl-Co A reductase(HMGR),low-density lipoprotein receptor(LDLR),adipose triglyceride lipase(ATGL),and fatty acid synthase(FAS),with consequent reduction of blood lipid levels and body weight;(ii)ACME enhanced total antioxidant capacity(T-AOC)and superoxide dismutase(SOD)activity in hepatic tissues;(iii)ACME reduced malondialdehyde(MDA)level and ameliorated lipid oxidative damage in liver.Our findings indicate that ACME is a strong candidate for development as a novel anti-hyperlipidemia and anti-obesity health product.
